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  • Antibiotics re-booted—time to kick back against drug resistance

    Antibiotics re-booted—time to kick back against drug resistance

  • Waring, M. J. et al. An analysis of the attrition of drug candidates from four major pharmaceutical companies. Nat. Rev. Drug Discov. 14, 475 (2015).

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  • Single-shot two-dimensional nano-size mapping of fluorescent molecules by ultrafast polarization anisotropy imaging

    Single-shot two-dimensional nano-size mapping of fluorescent molecules by ultrafast polarization anisotropy imaging

    System and principle of CUP2AI

    A simplified illustration of the system with 1 P excitation is given in Fig. 1. A detailed schematic for both 1 P and 2 P excitations can be found in Fig. S1 in Supplementary Information. All the used…

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  • Transcriptomic analysis reveals molecular mechanism by which Chinese olive fruit prolongs lifespan of Caenorhabditis elegans

    Transcriptomic analysis reveals molecular mechanism by which Chinese olive fruit prolongs lifespan of Caenorhabditis elegans

    Effects of COFE on survival time, body length, body width, locomotion capacity, lipofuscin, and stress resistance of C. elegans

    Totally, 34 substances were detected from the COFE, of which the main polyphenols were gallic…

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  • A cross-sectional survey of videoconferencing fatigue and its influencing factors during COVID-19 in the Chinese population

    A cross-sectional survey of videoconferencing fatigue and its influencing factors during COVID-19 in the Chinese population

    The cross-sectional study reported that the 291 participants had moderate levels of videoconferencing fatigue and found that the increased fatigue was significantly related to several factors, including greater technological complexity, worse…

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  • The IL-22–oncostatin M axis promotes intestinal inflammation and tumorigenesis

    The IL-22–oncostatin M axis promotes intestinal inflammation and tumorigenesis

    Epithelial OSMR induction in intestinal inflammation

    To investigate the cellular components of the OSM–OSMR axis in intestinal inflammation, we used the Helicobacter hepaticus + anti-IL-10R-induced colitis model9,10, which is characterized…

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  • Machine learning approach for identifying and forecasting streamflow droughts in data limited basins of South Korea using threshold levels

    Machine learning approach for identifying and forecasting streamflow droughts in data limited basins of South Korea using threshold levels

    Streamflow deficit characteristic based on threshold level method

    Fig. 1

    Sensitivity in Mean Drought Duration, Deficit Volume, and Intensity with Threshold levels (Q70, Q80, Q90, Q95, Q99) for each Dam: Soyanggang Dam (Dam 1), Andong Dam (Dam 2),…

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