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  • Mechanism of ATP hydrolysis in the Hsp70 BiP nucleotide-binding domain

    Mechanism of ATP hydrolysis in the Hsp70 BiP nucleotide-binding domain

    Theory

    The reaction space of the NBD is populated by the reaction scheme shown in Fig. 2a. It comprises 5 different states that are connected by 11 reaction equations of first and second order. We consider ATP hydrolysis an irreversible reaction…

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  • Detection of reproductive and hematobiochemical biomarkers to evaluate the impact of heavy metal exposure on brick kiln workers

    Detection of reproductive and hematobiochemical biomarkers to evaluate the impact of heavy metal exposure on brick kiln workers

    Ethical approval

    The study protocol was approved by the Bio-Ethical Committee of the Department of Zoology, Quaid-i-Azam University, Islamabad and has been assigned protocol #BEC-FBS-QAU2023-551. Additionally, the participants in the study…

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  • Bird mortality at wind farms in a tropical desert

    Bird mortality at wind farms in a tropical desert

    Study area

    The study was conducted during January 2020–September 2021 in 3000 km2 landscape of Indian Thar Desert in Jaisalmer, Rajasthan that included ~ 900 wind turbines (Fig. 6a). The region experiences arid bioclimate characterized by…

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  • Functional metabolites and inhibitory efficacy of kombucha beverage on pathogenic bacteria, free radicals and inflammation

    Functional metabolites and inhibitory efficacy of kombucha beverage on pathogenic bacteria, free radicals and inflammation

  • Paul Ross, R., Morgan, S. & Hill, C. Preservation and fermentation: past, present and future. Int. J. Food Microbiol. 79, 3–16. https://doi.org/10.1016/S0168-1605(02)00174-5 (2002).

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  • Effects of ultrasonic modification on physicochemical and structural properties of pomelo peel soluble dietary fiber extracted by alkali

    Effects of ultrasonic modification on physicochemical and structural properties of pomelo peel soluble dietary fiber extracted by alkali

    Materials

    Fresh white pomelos were purchased from Yibin Daily Shopping Supermarket (Sichuan, China), whose peels were stripped and washed, and cut into 2 cm pieces. Before extraction, the pomelo peels were dried in an oven at 60 °C until…

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  • Long-term pituitary function following transsphenoidal surgery for non-functional pituitary neuroendocrine tumor with apoplexy: a single-center retrospective analysis

    Long-term pituitary function following transsphenoidal surgery for non-functional pituitary neuroendocrine tumor with apoplexy: a single-center retrospective analysis

    A total of 563 patients who underwent transnasal surgery were included in this study. Of these, 65 patients were lost to follow-up, 5 patients were under 18 years of age, 94 patients had functional pituitary adenomas,19 patients had received…

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  • Association between spinopelvic parameters and postoperative urinary retention in thoracolumbar spine surgery: a propensity-matched analysis

    Association between spinopelvic parameters and postoperative urinary retention in thoracolumbar spine surgery: a propensity-matched analysis

    This study explored spinopelvic alignment as a novel risk factor for POUR in thoracolumbar spine surgery. Although POUR is a recognized postoperative complication with known risk factors such as advanced age, male sex, BPH, and prolonged…

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  • Association between cesarean delivery and childhood allergic diseases in a longitudinal population-based birth cohort from Japan

    Association between cesarean delivery and childhood allergic diseases in a longitudinal population-based birth cohort from Japan

    Study design, setting, and participants

    The Ministry of Health, Labour, and Welfare launched the Longitudinal Survey of Babies in the 21 st Century to investigate Japan’s declining birth rate18,19,20. This survey included 43,767 children born…

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  • Oral curative therapeutic study of N-nitrosodiethylamine-induced mouse liver damage of chitosan-coated ursolic acid niosomes

    Oral curative therapeutic study of N-nitrosodiethylamine-induced mouse liver damage of chitosan-coated ursolic acid niosomes

    The progressive increase in the particle size of Nio-UA-Cs following the addition of chitosan was caused by the latter’s accumulation on the niosome surface through electrostatic and hydrophobic interactions20. In addition, the coating of…

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