Analytical techniques for VOC detection in PD
Variation in VOC levels in PD have been explored across both pre-clinical and clinical studies with the aim of developing non-invasive tests for diagnosis and/or monitoring. The choice of the…
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Genomic landscape of estrogen receptor-positive HER2-negative advanced breast cancer with acquired resistance to aromatase inhibitors: Identification of an ESR1 alteration-related gene signature
SEER [Internet]. [cited 2024 Apr 11]. Female Breast Cancer Subtypes – Cancer Stat Facts. Available from: https://seer.cancer.gov/statfacts/html/breast-subtypes.html.
Burstein HJ. Systemic therapy for estrogen receptor-positive, HER2-negative…
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Magnetic reconnection as the driving factor behind high-mass protostellar luminosity flares
Maser variability
The variability of the integrated 6.668 GHz CH3OH maser flux during this flare is illustrated in Fig. 1. After the 6.668 GHz CH3OH maser in G36 reached its peak flux density on October 14, 202210, an extensive monitoring…
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Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with single-nucleus RNA-sequencing
Buchman, A. S. et al. Total daily physical activity and the risk of AD and cognitive decline in older adults. Neurology 78, 1323–1329 (2012).
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Author Correction: Immune phenotyping of diverse syngeneic murine brain tumors identifies immunologically distinct types
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate…
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Uncovering the hidden landscape of tumour antigens
T cell-based immunotherapies, such as chimeric antigen receptor (CAR) T cells, have transformed cancer treatments; however, their success has been limited to subsets of patients owing to the scarcity of truly tumour-specific antigens. Currently…
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Earth-mass planets with He atmospheres in the habitable zone of Sun-like stars
Observations of protoplanetary disks indicate that there can be several hundred Earth masses of pebbles embedded in each gas disk1. These pebbles vanish after a few million years, probably due to radial drift and planetesimal formation outside…
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UFMylation-dependent quality control of ER-stalled ribosomes
Although translation is highly processive, ribosomes stall when they are defective or encounter damaged mRNAs. Stalled ribosomes collide with other ribosomes, leading to non-conventional splitting that leaves a large (60S) subunit with an…
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In vivo epigenome editing with NovaIscB
Obligate mobile element guided activity is a class of RNA-guided nucleases such as IscB, the ancestor of Cas9. IscB has been used for genome editing, owing to its small size and large structured guiding RNA (ωRNA). Genome editors with improved…
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Better SIFI than sorry | Nature Structural & Molecular Biology
The ability of metazoan cells to remain attuned to challenging environmental cues such as temperature, osmotic and chemical stresses is essential for developmental resilience. To do so, cells use molecular pathways for stress response signaling….
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