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  • The brain works at more than 10 bits per second

    A recent article makes a claim with far-reaching implications for neuroscience, technology, and society: that the human brain is subject to an information processing ‘speed limit’ of 10 bits per second. Although this speed limit appears to…

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  • Detection and characterization of rare variants in NOTCH2NLC causing false negative molecular diagnosis through long-read sequencing

    Detection and characterization of rare variants in NOTCH2NLC causing false negative molecular diagnosis through long-read sequencing

  • Wu W, Yu J, Qian X, Wang X, Xu Y, Wang Z, et al. Intermediate-length CGG repeat expansion in NOTCH2NLC is associated with pathologically confirmed Alzheimer’s disease. Neurobiol Aging. 2022;120:189–95.

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  • Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis

    Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis

    ER–mitochondria contacts rapidly expand during ferroptosis

    To assess the dynamics of EMCS remodelling induced by lipid-ROS in real time, we first validated the induction of ferroptosis in our cellular model. We used the RAS-selective lethal…

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  • PET-based tracking of CAR T cells and viral gene transfer using a cell surface reporter that binds to lanthanide complexes

    PET-based tracking of CAR T cells and viral gene transfer using a cell surface reporter that binds to lanthanide complexes

    Cloning of plasmids

    Construction of plasmids, for example, for the production of retrovirus- and AAV-based vectors, was accomplished by standard cloning techniques. Sequence maps for DTPA-R and Colchi-R can be found in the Supplementary…

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  • Let the CAThepsin L out of the thymus

    Let the CAThepsin L out of the thymus

    Let the CAThepsin L out of the thymus

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  • Education of healthcare professionals to improve guideline adherence in atrial fibrillation: the STEEER-AF cluster-randomized clinical trial

    Education of healthcare professionals to improve guideline adherence in atrial fibrillation: the STEEER-AF cluster-randomized clinical trial

    Competing interests

    All principal authors have completed the International Committee of Medical Journal Editors (ICMJE) uniform disclosure form. D.K. declares support for the present manuscript as…

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