Human subjects
The human study was approved by The Prince Charles Hospital Human Research Ethics Committee (approval number: HREC/15/QPCH/7). A total of 25 subjects (age: 75.8 ± 7.07 [mean ± standard deviation] years; 12 males and 13…
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Recognizing American Sign Language gestures efficiently and accurately using a hybrid transformer model
Before initiating the training process, the dataset was divided into three subsets, allocating 80% for training, 10% for validation, and 10% for testing to maintain a balanced distribution across all categories. This stratified partitioning…
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K36-based inhibitor analogs as potential therapeutics against SARS-CoV-2 main protease (Mpro): a computational investigation
Docking studies
Based on initial cavity detection analysis, the docking process demonstrated that Mpro has more than one active site. The largest pocket (where K36 binds) is composed from twenty (20) amino acids (namely: Thr25, Thr26, Leu27,…
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Eco-friendly spectrofluorimetric determination of remdesivir in the presence of its metabolite in human plasma for therapeutic monitoring in COVID-19 patients
Given the urgent need for a sensitive and selective method to quantify REM in intravenous formulations and plasma, both for monitoring its stability and for therapeutic drug monitoring (TDM) during COVID-19 treatment protocols, it was essential…
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Transdiagnostic neuromodulation of impulsivity: current status and future trajectories
Crisp ZC, Grant JE. Impulsivity across psychiatric disorders in young adults. Compr Psychiatry. 2024;130:152449.
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Schaub A-C, Vogel M, Lang UE, Kaiser S, Walter M,…
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Green and white analytical approach for parallel quantification of gabapentin and methylcobalamin in medicinal products using inventive RP-HPLC technique
MET and GAB are determined simultaneously using HPLC methodologies, as well as the method’s white and green metrics as well as its efficacy as a pure dosage form.
Greenness and whiteness metrics were used to evaluate the sustainability of the…
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Safety and efficacy of live attenuated PEDV vaccines for neonatal protection
Cells and viruses
African green monkey kidney cells (Vero-CCL81) were maintained in Dulbecco’s modified Eagle’s medium (DMEM, Lonza BE12-741F) supplemented with 10% fetal bovine serum (Bodinco). PEDVs were grown in Vero cells in maintenance…
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Eco-friendly spectrophotometric quantification of the potential combination of mirabegron and tamsulosin
Alexandre, E. C. et al. Mirabegron relaxes urethral smooth muscle by a dual mechanism involving β3-adrenoceptor activation and α1‐adrenoceptor Blockade. Br. J. Pharmacol. 173, 415–428. https://doi.org/10.1111/bph.13367 (2016).
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An adaptive AI-based virtual reality sports system for adolescents with excess body weight: a randomized controlled trial
REVERIE system
Setup of the professional coaching panel
Since adolescents with excess body weight lacked standardized sports skills, we established standardized sports protocols for table tennis and soccer. To achieve this, we convened ten…
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Synergistic targeting of cancer cells through simultaneous inhibition of key metabolic enzymes
Cell culture
iFTSECs [88] were purchased from abm® (FT240, cat. #T0762-GVO-ABM). Cells were grown in DMEM/F-12 GlutaMAX supplemented with 10% fetal bovine serum, 100 U/ml penicillin and 100 µg/ml streptomycin at 37 °C with 5% CO2. Empty…
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