Researchers feed vast quantities of genomic data into machine-learning systems to train them to predict the role of non-coding sequences.Credit: JuSun/iStock via Getty
Nearly 25 years after scientists completed a draft human genome sequence, many…
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Spatial multi-omics of nuclear architecture with two-layer seqFISH+
The mammalian nucleus is organized into higher-order structures that orchestrate cell-type-specific gene expression programmes. Technologies that directly and simultaneously measure spatial relationships between DNA, RNA and protein molecules…
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A long-lost species | Nature Reviews Microbiology
White-nose disease is a fungal disease in bats that is caused by Pseudogymnoascus destructans. The pathogen is widely distributed in Eurasia and has been recently introduced to North America. Previous studies have explored host–fungus…
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Presence of viable gram-positive bacteria in blood of patients with inflammatory bowel disease is not affected by treatment
Patients and study design
The study included 47 consecutive patients with either Crohn’s disease (CD, n = 28) or ulcerative colitis (UC, n = 19) controlled at the outpatient clinic coming for regular check-ups at the Department of…
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Coordinated early immune response in the lungs is required for effective control of SARS-CoV-2 replication
Frei, A. et al. Development of hybrid immunity during a period of high incidence of omicron infections. Int. J. Epidemiol. 52, 1696–1707 (2023).
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Spatiotemporal orchestration of mitosis by cyclin-dependent kinase
Grallert, A. et al. Centrosomal MPF triggers the mitotic and morphogenetic switches of fission yeast. Nat. Cell Biol. 15, 88–95 (2013).
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Hachet, V.,…
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Low frequency oscillations – neural correlates of stability and flexibility in cognition
Data
We analyzed two independent MEG-datasets to identify low-frequency synchronized networks supporting vsWM. The first dataset consisted of MEG and behavioral data from 83 participants in the Human Connectome Project (HCP,
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ETMR stem-like state and chemo-resistance are supported by perivascular cells at single-cell resolution
Single-cell transcriptomics of murine and human ETMRs identified three distinct subpopulations of malignant cells with a predominance of self-renewing states
To understand the cellular diversity of ETMR, we analyzed single-cell and single-nuclei…
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The mitochondrial methylation potential gates mitoribosome assembly
Mouse husbandry and tissue collection
Slc25a26 conditional KO mice (SamcloxP/loxP) were generated previously by Taconic Biosciences (Germany), by flanking exon 3 of the National Center for Biotechnology Information (NCBI) transcript NM_026255.5…
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