Main findings and interpretation
This study aimed to explore whether smoking causes OA in both sexes and to explore the mediating effect of obesity. The results suggest that smoking can lead to an increased risk of OA, and that this effect is more…
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Personalized cancer treatment strategies incorporating irreversible and reversible drug resistance mechanisms
Model overview
We developed a joint mathematical model that incorporates both reversible and irreversible resistance mechanisms to simulate virtual patients’ outcomes under different treatment strategies. We give a high-level overview of the…
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Interpretable representation learning for 3D multi-piece intracellular structures using point clouds
A framework for morphology-appropriate representation learning
The 3D rotation-invariant representation learning framework has two main components. The first component addresses a critical issue in biological image analysis that is capturing…
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Suppression of multiple mouse models of refractory malignancies by reprogramming IL-18 ligand-receptor interaction
Oncolytic virus upregulates IL-18 receptor expression in the TME
Our previous study demonstrated that the M1 virus effectively suppresses murine melanoma B16F10 in vivo and shapes the TME into an inflammatory state; however, its antitumor effect is…
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Trials for LLM-supported clinical decisions in African primary healthcare
Competing interests
M.M. is an employee of the primary funder of the studies but made substantial (independent) intellectual contributions to the design of the grant and studies. The decision to publish…
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A functional neuroimaging biomarker of mild cognitive impairment using TD-fNIRS
General description
The two participant groups, MCI and age-matched HC (Table 1) wore the Kernel Flow2 TD-fNIRS headset and their neurophysiological data was measured while they performed cognitive tasks: Verbal Fluency and N-Back working memory…
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Halomonas sp. MC140, a polyhydroxyalkanoate (PHA) producer isolated from the Arctic environment
Rehm, B. H. Bacterial polymers: Biosynthesis, modifications and applications. Nat. Rev. Microbiol. 8, 578–592. https://doi.org/10.1038/nrmicro2354 (2010).
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Impact of conventional cigarette and electronic cigarette use on sperm quality and IVF/ICSI outcomes
Study population and design
Inclusion criteria
Between May 2022 and January 2024, a total of 151 conventional cigarette smokers and 145 E-cigarette smokers, all undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) at a…
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Interleukin-35 impairs human NK cell effector functions and induces their ILC1-like conversion with tissue residency features
Human samples
Healthy human blood (collected in EDTA anticoagulant-containing tubes) was purchased anonymously from the French blood agency (Etablissement Français du sang, Lyon France, convention 16-093). Participants were French voluntary…
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Decoding 3D cell morphology with interpretable point cloud models
Vasan, R. et al. Nat. Methods https://doi.org/10.1038/s41592-025-02729-9 (2025).
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Stringer, C., Wang, T., Michaelos, M. & Pachitariu, M. Nat. Methods 18, 100–106 (2021).
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