Simulations
The performance of phylogenetically informed prediction on ultrametric trees
Here, we assess the performance of phylogenetically informed predictions compared to OLS and PGLS-derived predictive equations under different evolutionary…
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Direct observation of distinct bulk and edge nonequilibrium spin accumulation in ultrathin MoTe2
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Jungwirth, T., Wunderlich, J. & Olejník, K. Spin Hall effect devices. Nat. Mater. 11,…
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Selective identification of polyploid hepatocellular carcinomas with poor prognosis by artificial intelligence-based pathological image recognition
Development of an AI-based image recognition model to estimate HCC ploidy
First, we constructed a model to evaluate the ploidy status of HCC using deep learning and CNN-based image classification. A total of 44 cases whose ploidy status had been…
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VISTA is a potential target for immunotherapy in B-cell acute lymphoblastic leukemia in children
Malard, F. & Mohty, M. Acute lymphoblastic leukaemia. Lancet 395, 1146–1162. https://doi.org/10.1016/S0140-6736(19)33018-1 (2020).
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Pulte, D., Gondos, A. &…
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Topological layer Hall effect in two-dimensional type-I multiferroic heterostructure
Coupling magnetic skyrmion and layer physics
Since our target is to generate the coupling between magnetic skyrmion and layer physics, the systems studied here should be multilayers with layer polarization and time-reversal symmetry breaking. We…
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Composition of the freshwater decapod crustacean communities in an area of mining in Brazilian Amazonia and the variation related to environmental parameters
Ye, H., Zeng, C., Tsutsui, N. & Dircksen, H. Editorial: Crustacean reproductive physiology and its applications. Front. Physiol. 13, 85 (2022).
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Wacker, A. & Harzsch, S….
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MuTATE: an interpretable multi-endpoint machine learning framework for automated molecular subtyping in cancer
Demographic and clinical characteristics were significantly different between cohorts (Supplementary Data 2). Supplementary Data 2 offers detailed clinical and demographic breakdowns that reveal key differences in age, race, and survival across…
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Erythropoietin decreases apoptosis and promotes Schwann cell repair and phagocytosis following nerve crush injury in mice
Transcriptomic alterations in injured nerve cells following SNCI were systematically studied using bulk RNA sequencing. Figure 1 illustrates the experimental processes, including SNCI, EPO dosing, tissue harvesting, RNA extraction, and library…
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AI meets physics in computational structure-based drug discovery for GPCRs
Oprea, T. I. et al. Unexplored therapeutic opportunities in the human genome. Nat. Rev. Drug Discov. 17, 317–332 (2018).
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Hauser, A….
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Differential immunity induced by Omicron sublineages in naïve and vaccine breakthrough infections
Study cohort
This study included 278 plasma samples collected from July 2021 through June 2023 from 170 COVID-19 patients, of whom 157 (92.4%) were hospitalized, 130 (76.5%) were fully vaccinated with 2 doses of the ancestral SARS-CoV-2 vaccine,…
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