Using artificial intelligence, researchers show how γ-secretase recognizes substrates – an important advance for fundamental and translational research.
The γ-secretase enzyme is capable of cleaving more than 150 different…
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Enhancement mechanisms of coal permeability under water saturated conditions using liquid nitrogen freeze thaw cycles
Specimen preparation
The experimental coal samples were taken from the No.3 coal seam of 7107 working Face of Lu’an Wang zhuang Coal Mine in Chang zhi, Shanxi Province, which has a simple structure, low ash, and low sulfur, and were sealed with…
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Towards energy-efficient joint relay selection and resource allocation for D2D communication using hybrid heuristic-based deep learning
Conventional algorithm: MRFO
Numerous real-world optimization issues are relatively becoming difficult. Meta-heuristic approaches for managing the complexity of optimization issues are highly becoming famous. One of the nature-motivated…
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Improving microvascular brain analysis with adversarial learning for OCT–TPM vascular domain translation
This section details the methodology employed in our work, beginning with the initial stages of data collection and preparation, the techniques used for image generation and analysis, and the procedures we followed for methodology validation.
Data…
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3D printing of a low-cost videolaryngoscope for tracheal intubation
This study describes the three development stages of a videolaryngoscope using 3D printing technology: prospecting, modeling and prototyping, and realistic simulation on airway mannequins. The modeling, prototyping, and simulation phases were…
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Computational exploration of global venoms for antimicrobial discovery with Venomics artificial intelligence
Mining venoms for antimicrobials
We sourced venom proteins from four databases: ConoServer (focusing on conopeptides, Supplementary Fig. 1)31, ArachnoServer (spider proteins, Supplementary Fig. 2)32, ISOB (indigenous snake proteins, Supplementary…
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Genetic and environmental contributions to the link between synaesthesia and neurodevelopmental and psychiatric features: a twin study
Ward J. Synesthesia. Annu Rev Psychol. 2013;64:49–75.
Google Scholar
Root NB, Rouw R, Asano M, Kim CY, Melero H, Yokosawa K, et al. Why is the synesthete’s “A” red? Using a five-language…
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CD20-bearing extracellular vesicles are associated with prognostic biomarkers of patients with AIDS-NHL
AIDS Malignancy Consortium (AMC) 034 study population
The AIDS Malignancy Consortium (AMC) trial, AMC protocol #034 (AMC-034) compared infusional combination chemotherapy (EPOCH: etoposide, vincristine, doxorubicin, cyclophosphamide, and…
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Applications and research trends in organoid based infectious disease models
Organoid definition
Organoids are small 3D organ-like structures formed from embryonic stem cells (ESCs), adult stem cells (ASCs), or induced pluripotent stem cells (iPSCs) or primary human tissues through self-renewal, differentiation, and…
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Improved approaches to genotyping MAOA-uVNTR polymorphisms with novel allele discovery
In the present study, automated fluorescent analysis of PCR products by capillary electrophoresis offers superior resolution and improved sensitivity, representing a significant improvement over traditional PCR followed by gel electrophoresis…
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