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The defensome of prokaryotes in aquifers
The vast reservoir of prokaryotic defensome in groundwater
We established a metagenomic groundwater prokaryotic defensome catalog (GPDC) (see Supplementary Figs. S1, S2 for an overview), encompassing 190,810 defense genes, 90,824 defense systems,…
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Long-term benefits of TUDCA supplement in ARSACS zebrafish model
Bouhlal, Y., Amouri, R., Euch-Fayeche, E., Hentati, F. & G. & Autosomal recessive spastic ataxia of Charlevoix–Saguenay: An overview. Parkinsonism Relat. Disord. 17, 418–422 (2011).
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Phase separated condensates of ATRX regulate neural progenitor identity
Human iPSC (hiPSC) culture
The human iPSC control lines (1210B2 and RPC771 (ReproCELL)) and the genome-edited derivative of RPC771 (ΔEx15) were maintained as previously described50,65. The cells were cultured under feeder-free conditions in…
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Can obesity pharmacotherapy be used to manage male infertility?
Can obesity pharmacotherapy be used to manage male infertility?
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Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells
Stem cells and their differentiated progeny differ metabolically; recent studies indicate that metabolic rewiring controls changes in cell fate (reviewed in ref. 7). However, whether the functional heterogeneity found in tissue stem cells is…
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Early identification of individuals at risk for multiple sclerosis by quantification of EBNA-1381-452-specific antibody titers
Establishment of EBNA-1381-452-specific IgG ELISA
First, the EBNA-1381-452-specific IgG ELISA was established and validated using an EBNA-1381-452-derived peptide pool as antigen. The test showed low inter- and intra-assay variability, as assessed…
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Structure-guided engineering of snake toxins for selective modulation of adrenergic and muscarinic receptors
Expression, purification and biotin labeling of MT3 and engineering variants
The coding sequence of muscarinic toxin 3 (MT3) was cloned into the pME vector (derived from AbVec2.0-IGHG1) with an N-terminal human trypsinogen-2 (TRYP2) signal…
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The Helicobacter pylori AI-clinician harnesses artificial intelligence to personalise H. pylori treatment recommendations
Ethics statement
The Hp-EuReg study was conducted in accordance with the ethical principles outlined in the Declaration of Helsinki (1975, and its subsequent revisions) and complied with all relevant institutional and national ethical regulations….
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iCAFs control chemoresistance | Nature Reviews Urology
Distinct populations of cancer-associated fibroblasts (CAFs) that influence therapy response have been discovered in bladder cancer. Inflammatory CAFs (iCAFs) support the expansion of cancer stem cells, driving chemoresistance and providing…
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