Ethics information
All animal procedures were conducted in compliance with national and international ethical guidelines and regulations. Mouse experiments were approved by the local animal welfare authorities at Heidelberg University Interfaculty…
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Potential diagnostic and therapeutic gene in chronic low back pain through pyroptosis modulation: A silico study based on the dataset analysis
The study’s workflow diagram is depicted in Fig. 1.
Fig. 1 Differentially gene expression
Comparing chronic LBP against acute LBP groups revealed a total of 883 DEGs (|log2Fold Change|> 0, FDR corrected p-value < 0.05). Within the cLBP…
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Single-cell spatial analysis with Xenium reveals anti-tumour responses of CXCL13 + T and CXCL9+ cells after radiotherapy combined with anti-PD-L1 therapy
Study objectives and design
The aim of this study was to elucidate alterations in the immune environment after treatment with anti-PD-L1-CRT and to investigate the underlying mechanisms at the single-cell level via use of Xenium. First, we…
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Computerised analysis of non-conjugate spiral bevel gear mesh using an advanced and fast-converging tooth contact model
Proposed novel TCA method
In the new model, surface tangency conditions were employed to depict the contact of bevel gear teeth, as illustrated in Fig. 1. These conditions apply to the \(C^1\) continuous surfaces \(\Sigma _1\) and \(\Sigma…
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Combined genome-wide association study of facial traits in Europeans increases explained variance and improves prediction
C-GWAS and replication highlight 62 novel face loci
The C-GWAS discovery phase included 11,662 individuals of European descent from five cohorts (Supplementary Table 1 and see the “Methods” section): the Rotterdam Study (RS, N = 4242), the…
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Functionally diverse human insular architecture with memory-related hippocampal interactions
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Huang, W. et al. Direct interactions between the human insula and hippocampus during…
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Developing an explainable machine learning and fog computing-based visual rating scale for the prediction of dementia progression
Nguyen Gia, T., et al. Low-cost fog-assisted healthcare IoT system with energy-efficient sensor nodes. 2017 13th International Wireless Communications on Mobile Computing Conference IWCMC 2017, pp. 1765–1770, 2017.
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Hydroxysafflor Yellow A modulation of metabolite networks and inhibition of JAK2/STAT1 pathway in sepsis
HYSA improved survival rate in CLP mice
To evaluate the efficacy of HYSA (Fig. 1A) on survival in CLP-induced septic mice, the drug was administered four hours post-CLP surgery. Given that the inflammatory response peaks at 24 h, the mice were…
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Design and control of LCC DVR
The schematic diagram of LCC DVR is shown in Fig. 1. The power circuit of the LCC DVR consists of a three phase shunt converter, three series inverters and injection transformers. The phase voltage distortions are compensated individually…
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Contextual information based anomaly detection for multi-scene aerial videos
Proposed model
This study proposes an object-centric multi-scene video anomaly detection algorithm for UAV surveillance videos. Figure 1 shows the overview of the proposed UAV based anomaly detection system. In this work, an object-centric…
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