Animals
All the animal experiments were approved by the Ethics Committee of the Animal Laboratory of Kunming Medical University (no. Kmmu20231512). The Laboratory Animal Centre at Kunming Medical University provided 1, 2, 4, 6, and 8-week-old,…
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Optimal dosing of anti-cancer treatment under drug-induced plasticity
Model of cell proliferation and phenotypic switching
Our baseline model is a multi-type branching process model in continuous time54. In the model, cells switch stochastically between two distinct cell states, a drug-sensitive (type-0) and a…
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Step-stress accelerated degradation test for Inverse Gaussian process based on M-optimality criterion
In this section, we illustrate the proposed procedure with the widely used stress relaxation data in28 (Example 8.7, p.351). In addition, a comparison will be made between our optimal design and the traditional criteria design.
Stress relaxation…
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A novel machine learning framework for stroke type identification in resource constrained settings with robustness to missing data
This research aimed to develop a robust machine learning model for distinguishing between ischemic (IS) and hemorrhagic (HS) strokes solely using clinical attributes, without relying on neuroimaging data. We addressed key challenges including…
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Directed evolution-based discovery of ligands for in vivo restimulation of chimeric antigen receptor T cells
Clinical trial data
Paediatric B-ALL
Patient data from two studies of tisagenlecleucel for the treatment of CD19-positive relapsed or refractory B-ALL in children and young adults, NCT01626495 (n = 60 infused)18 and NCT02906371 (n = 70…
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Twenty years of tuberculosis-driven selection shaped the evolution of the meerkat major histocompatibility complex
Fijarczyk, A. & Babik, W. Detecting balancing selection in genomes: limits and prospects. Mol. Ecol. 24, 3529–3545 (2015).
Google Scholar
Kloch, A. et al. Signatures of balancing…
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Deep dictionary learning with reconstruction for texture recognition
Experimental setting
To validate our method, we utilized the LMT-108 dataset46 containing 108 different objects which are divided into 9 categories: 1) Meshes; 2) Stones; 3) Glossy; 4) Wood Types; 5) Rubbers; 6) Fibers; 7) Foams; 8) Foils and…
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Genetically programmable optical random neural networks
Numerical studies
Before constructing the experimental setup, we make use of an accurate beam propagation method (BPM) simulation to validate our main idea of controlling optical random projection. The details of the simulation are given in…
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Servant leadership effects on teacher wellbeing and enthusiasm in Turkish schools and the moderating influence of distributed leadership
Vergara, C. R. & Grit Self-efficacy and goal orientation: A correlation to achievement in statistics. Int. J. Educ. Res. 8, 89–106 (2020).
Acton, R. & Glasgow, P. Teacher well-being in…
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Prediction of exosomal miRNA-based biomarkers for liquid biopsy
Data collection and preprocessing
In this study, datasets were created using the data extracted from the databases: RNALocate and miRbase37,38. We collected the experimentally validated exosomal miRNA sequences from RNALocate. It contained about…
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