Rare human TUB variants impair leptin sensitivity through disruption of STAT3 activation, leading to hyperphagic obesity.
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The TUB variant impairs leptin sensitivity and AgRP neuronal response, leading to obesity | Science Translational Medicine
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Lactylation fuels nucleotide biosynthesis and facilitates deuterium metabolic imaging of tumor proliferation in preclinical models of H3K27M-mutant gliomas | Science Translational Medicine
H3K27M-driven lactylation facilitates nucleotide biosynthesis, an effect that can be exploited for metabolic imaging of disease progression in DMGs.
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Erratum for the Research Article “A rationally designed cocktail of nanobodies elicited by heterologous vaccination confers protection against SFTSV in preclinical models” | Science Translational Medicine
In the Research Article “A rationally designed cocktail of nanobodies elicited by heterologous vaccination confers protection against SFTSV in preclinical models” by X. Wu et al., Fig. 4E was erroneously duplicated as Fig. 4H. Figure 4H has…
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Multiomic analyses of longitudinal plasma samples identify thromboinflammation endotypes and trajectories in patients with trauma | Science Translational Medicine
Analyses of longitudinal plasma samples from patients with trauma identify biological states that determine divergent thromboinflammatory outcomes.
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Metabolic acidosis causes a Fanconi-like syndrome with intracellular trafficking defects and proximal tubule dysfunction | Science Translational Medicine
Renal proximal tubules are sensitive to metabolic acidosis.
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Parenteral vaccination with an adjuvanted mRNA vaccine induces protective mucosal immunity against rotavirus in neonatal mice | Science Translational Medicine
An Am80-loaded mRNA-LNP vaccine against rotavirus elicits intestinal mucosal immunity in mice and pigs and protects neonatal mice against infection.
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Meridian raises $17 million to remake the agentic spreadsheet
The fight to tame spreadsheets with AI isn’t over yet. A new company called Meridian has emerged from stealth with a more comprehensive IDE-based approach to agentic financial modeling — and plenty of funding to build it. On Wednesday, the…
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Reusable launch vehicles will change everything in space, and on Earth
“When you have a fully reusable vehicle … you can send it anywhere … to the moon … past Mars” —Jared Isaacman, NASA Administrator. Imagine a future where thousands of people travel to space every year. Some stay a week. Some a…
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James Webb Space Telescope uncovers secret supermassive black holes that escape traditional detection
Woven through the universe are forces, often unseen, that dictate its grand design. For example, at the very heart of nearly every galaxy, we find a supermassive black hole. This isn’t just some cosmic void — it’s a powerful engine.
Even in…
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‘Dark Matter’ in Your Genome Could Unlock New Disease Treatments : ScienceAlert
Although there are striking differences between the cells that make up your eyes, kidneys, brain, and toes, the DNA blueprint for these cells is essentially the same. Where do those differences come from?
Scientists are realizing the defining…
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