McKenney, R. J., Huynh, W., Tanenbaum, M. E., Bhabha, G. & Vale, R. D. Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes. Science 345, 337–341 (2014).
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RYK is a GPNMB receptor that drives MASH
Do, A., Zahrawi, F. & Mehal, W. Z. Therapeutic landscape of metabolic dysfunction-associated steatohepatitis (MASH). Nat. Rev. Drug Discov. 24, 171–189 (2025).
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…Continue Reading
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Gene editing treats a mouse model of a neurodevelopmental disorder
Yang, K. et al. Nature https://doi.org/10.1038/s41586-026-10113-6 (2026).
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Alendar, A. & Berns, A. Gene Dev. 35, 1403–1430 (2021).
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In vivo base editing of Chd3 rescues behavioural abnormalities in mice
Genetically modified mice
All experimental protocols and animal care and handling were approved by the Ethics Committee of Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (XHEC-F-2024-086). The bicistronic expression…
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Nucleotide signals coordinate activation and inhibition of bacterial immunity
Goldstone, D. C. et al. HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase. Nature 480, 379–382 (2011).
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Tal,…
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Single-cell and isoform-specific translational profiling of the mouse brain
Molecular cloning and AAV production
The original Ribo-STAMP construct consisted of a Tet-On hRPS2–APOBEC lentiviral expression vector, with a human phosphoglycerate kinase (PGK) promoter driving the expression of rtTA and pac, designed for…
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Laser writing in glass for dense, fast and efficient archival data storage
Key metrics
We evaluate the Silica storage system against the following metrics:
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Voxel quality, Q = B/nV, is an average (bit per voxel) calculated from the number of user bits, B, stored in a large number…
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Integrase anchors viral RNA to the HIV-1 capsid interior
Recombinant proteins
The vector pCPH6P-HIV1-IN used for bacterial expression of HIV-1 IN with a cleavable hexahistidine (His6) tag was previously described45. To obtain pCPH6P-SIVtal-IN, the DNA region encoding HIV-1 IN was replaced with a…
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Highly dynamic dural sinuses support meningeal immunity
Coles, J. A., Myburgh, E., Brewer, J. M. & McMenamin, P. G. Where are we? The anatomy of the murine cortical meninges revisited for intravital imaging, immunology, and clearance of waste from the brain. Prog. Neurobiol. 156, 107–148 (2017).
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Performance optimization of wire EDM of Nitinol shape memory alloy using BBD RSM and TLBO with alumina nano graphene and MWCNT Powder mixed dielectric
Rodrigues, P. F. & Oliveira, J. P. Functional performance of shape memory alloys. In Additive Manufacturing of Shape Memory Materials 15–51 (Elsevier, 2025).
Singh, R. et al. EDM-based…
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