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Gene editing treats a mouse model of a neurodevelopmental disorder
Yang, K. et al. Nature https://doi.org/10.1038/s41586-026-10113-6 (2026).
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Alendar, A. & Berns, A. Gene Dev. 35, 1403–1430 (2021).
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Integrated photonics enabling ultra-wideband fibre–wireless communication
Design and fabrication of the integrated modulator and modified UTC-PD
The TFLN modulator is fabricated on a 360-nm-thick X-cut single-crystalline LN thin film bonded on a 2.5-µm silicon dioxide layer sitting on a quartz substrate (NanoLN)….
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Single-cell and isoform-specific translational profiling of the mouse brain
Molecular cloning and AAV production
The original Ribo-STAMP construct consisted of a Tet-On hRPS2–APOBEC lentiviral expression vector, with a human phosphoglycerate kinase (PGK) promoter driving the expression of rtTA and pac, designed for…
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Personalized mRNA vaccine induces strong, durable immunity in hard-to-treat breast cancer
- CLINICAL BRIEFINGS
In an experimental trial, a personalized mRNA…
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What we know about autism and ageing — and what we don’t
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Highly dynamic dural sinuses support meningeal immunity
Coles, J. A., Myburgh, E., Brewer, J. M. & McMenamin, P. G. Where are we? The anatomy of the murine cortical meninges revisited for intravital imaging, immunology, and clearance of waste from the brain. Prog. Neurobiol. 156, 107–148 (2017).
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Nucleotide signals coordinate activation and inhibition of bacterial immunity
Goldstone, D. C. et al. HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase. Nature 480, 379–382 (2011).
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Laser writing in glass for dense, fast and efficient archival data storage
Key metrics
We evaluate the Silica storage system against the following metrics:
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Voxel quality, Q = B/nV, is an average (bit per voxel) calculated from the number of user bits, B, stored in a large number…
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An agentic system for rare disease diagnosis with traceable reasoning
We introduce DeepRare—an agentic framework designed to support rare disease diagnosis, structured upon a modular, multi-tiered architecture. The system comprises three core components: (1) a central host agent, equipped with a memory bank that…
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