Do, A., Zahrawi, F. & Mehal, W. Z. Therapeutic landscape of metabolic dysfunction-associated steatohepatitis (MASH). Nat. Rev. Drug Discov. 24, 171–189 (2025).
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Gene editing treats a mouse model of a neurodevelopmental disorder
Yang, K. et al. Nature https://doi.org/10.1038/s41586-026-10113-6 (2026).
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Alendar, A. & Berns, A. Gene Dev. 35, 1403–1430 (2021).
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Reduced cyclin D3 expression in erythroid cells protects against malaria
Cell lines and primary cell cultures
All cells were cultured under 5% CO2 at 37 °C. HEK-293T and COS7 cells (ATCC) were cultured in Dulbecco’s modified Eagle’s medium (DMEM) with 10% heat-inactivated fetal bovine serum (FBS) (Gibco), 1%
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Highly dynamic dural sinuses support meningeal immunity
Coles, J. A., Myburgh, E., Brewer, J. M. & McMenamin, P. G. Where are we? The anatomy of the murine cortical meninges revisited for intravital imaging, immunology, and clearance of waste from the brain. Prog. Neurobiol. 156, 107–148 (2017).
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Laser writing in glass for dense, fast and efficient archival data storage
Key metrics
We evaluate the Silica storage system against the following metrics:
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Voxel quality, Q = B/nV, is an average (bit per voxel) calculated from the number of user bits, B, stored in a large number…
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Personalized mRNA vaccine induces strong, durable immunity in hard-to-treat breast cancer
- CLINICAL BRIEFINGS
In an experimental trial, a personalized mRNA…
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In vivo base editing of Chd3 rescues behavioural abnormalities in mice
Genetically modified mice
All experimental protocols and animal care and handling were approved by the Ethics Committee of Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (XHEC-F-2024-086). The bicistronic expression…
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Nucleotide signals coordinate activation and inhibition of bacterial immunity
Goldstone, D. C. et al. HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase. Nature 480, 379–382 (2011).
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Tal,…
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Mid-cycle update
The hum started in my teeth.
At first, I thought it was just another sleepless night, another jittery caffeine tremor from too many energy drinks. But then my fillings began vibrating in time with the flickering street lights outside my…
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Integrase anchors viral RNA to the HIV-1 capsid interior
Recombinant proteins
The vector pCPH6P-HIV1-IN used for bacterial expression of HIV-1 IN with a cleavable hexahistidine (His6) tag was previously described45. To obtain pCPH6P-SIVtal-IN, the DNA region encoding HIV-1 IN was replaced with a…
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