Cell lines and primary cell cultures
All cells were cultured under 5% CO2 at 37 °C. HEK-293T and COS7 cells (ATCC) were cultured in Dulbecco’s modified Eagle’s medium (DMEM) with 10% heat-inactivated fetal bovine serum (FBS) (Gibco), 1%
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Reduced cyclin D3 expression in erythroid cells protects against malaria
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Roles of microtubules and LIS1 in dynein transport machinery assembly
McKenney, R. J., Huynh, W., Tanenbaum, M. E., Bhabha, G. & Vale, R. D. Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes. Science 345, 337–341 (2014).
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RYK is a GPNMB receptor that drives MASH
Do, A., Zahrawi, F. & Mehal, W. Z. Therapeutic landscape of metabolic dysfunction-associated steatohepatitis (MASH). Nat. Rev. Drug Discov. 24, 171–189 (2025).
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Gene editing treats a mouse model of a neurodevelopmental disorder
Yang, K. et al. Nature https://doi.org/10.1038/s41586-026-10113-6 (2026).
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Alendar, A. & Berns, A. Gene Dev. 35, 1403–1430 (2021).
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Highly dynamic dural sinuses support meningeal immunity
Coles, J. A., Myburgh, E., Brewer, J. M. & McMenamin, P. G. Where are we? The anatomy of the murine cortical meninges revisited for intravital imaging, immunology, and clearance of waste from the brain. Prog. Neurobiol. 156, 107–148 (2017).
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In vivo base editing of Chd3 rescues behavioural abnormalities in mice
Genetically modified mice
All experimental protocols and animal care and handling were approved by the Ethics Committee of Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (XHEC-F-2024-086). The bicistronic expression…
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Single-cell and isoform-specific translational profiling of the mouse brain
Molecular cloning and AAV production
The original Ribo-STAMP construct consisted of a Tet-On hRPS2–APOBEC lentiviral expression vector, with a human phosphoglycerate kinase (PGK) promoter driving the expression of rtTA and pac, designed for…
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Laser writing in glass for dense, fast and efficient archival data storage
Key metrics
We evaluate the Silica storage system against the following metrics:
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Voxel quality, Q = B/nV, is an average (bit per voxel) calculated from the number of user bits, B, stored in a large number…
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Personalized mRNA vaccine induces strong, durable immunity in hard-to-treat breast cancer
- CLINICAL BRIEFINGS
In an experimental trial, a personalized mRNA…
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Nucleotide signals coordinate activation and inhibition of bacterial immunity
Goldstone, D. C. et al. HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase. Nature 480, 379–382 (2011).
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Tal,…
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