Design and fabrication of the integrated modulator and modified UTC-PD
The TFLN modulator is fabricated on a 360-nm-thick X-cut single-crystalline LN thin film bonded on a 2.5-µm silicon dioxide layer sitting on a quartz substrate (NanoLN)….
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Roles of microtubules and LIS1 in dynein transport machinery assembly
McKenney, R. J., Huynh, W., Tanenbaum, M. E., Bhabha, G. & Vale, R. D. Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes. Science 345, 337–341 (2014).
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In vivo base editing of Chd3 rescues behavioural abnormalities in mice
Genetically modified mice
All experimental protocols and animal care and handling were approved by the Ethics Committee of Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (XHEC-F-2024-086). The bicistronic expression…
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An agentic system for rare disease diagnosis with traceable reasoning
We introduce DeepRare—an agentic framework designed to support rare disease diagnosis, structured upon a modular, multi-tiered architecture. The system comprises three core components: (1) a central host agent, equipped with a memory bank that…
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Single-cell and isoform-specific translational profiling of the mouse brain
Molecular cloning and AAV production
The original Ribo-STAMP construct consisted of a Tet-On hRPS2–APOBEC lentiviral expression vector, with a human phosphoglycerate kinase (PGK) promoter driving the expression of rtTA and pac, designed for…
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Personalized mRNA vaccine induces strong, durable immunity in hard-to-treat breast cancer
- CLINICAL BRIEFINGS
In an experimental trial, a personalized mRNA…
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RYK is a GPNMB receptor that drives MASH
Do, A., Zahrawi, F. & Mehal, W. Z. Therapeutic landscape of metabolic dysfunction-associated steatohepatitis (MASH). Nat. Rev. Drug Discov. 24, 171–189 (2025).
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Gene editing treats a mouse model of a neurodevelopmental disorder
Yang, K. et al. Nature https://doi.org/10.1038/s41586-026-10113-6 (2026).
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Alendar, A. & Berns, A. Gene Dev. 35, 1403–1430 (2021).
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Highly dynamic dural sinuses support meningeal immunity
Coles, J. A., Myburgh, E., Brewer, J. M. & McMenamin, P. G. Where are we? The anatomy of the murine cortical meninges revisited for intravital imaging, immunology, and clearance of waste from the brain. Prog. Neurobiol. 156, 107–148 (2017).
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Laser writing in glass for dense, fast and efficient archival data storage
Key metrics
We evaluate the Silica storage system against the following metrics:
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Voxel quality, Q = B/nV, is an average (bit per voxel) calculated from the number of user bits, B, stored in a large number…
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