Armoring CAR T cells with the ability to secrete VEGF-neutralizing single-chain variable fragments enhances potency and control of tumors in vivo.
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Engineering CAR T cells to secrete VEGF-neutralizing scFvs enhances antitumor activity against solid tumors | Science Translational Medicine
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Modulating alternative splicing of MECP2 is a potential therapeutic strategy for Rett syndrome | Science Translational Medicine
Switching of MECP2-e2 to the more efficiently translated e1 isoform up-regulates MeCP2 protein and rescues deficits in RTT iPSC-derived neurons.
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Cell-free DNA fragmentomes for noninvasive detection of liver cirrhosis and other diseases | Science Translational Medicine
Genome-wide cfDNA fragmentomes are altered in liver disease and other morbidities and enable noninvasive detection of liver fibrosis and cirrhosis.
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Epigenetically regulated pancreatic GABA-somatostatin signaling underlies gestational diabetes–induced glucose intolerance in offspring | Science Translational Medicine
TET-controlled GABA-somatostatin signaling in pancreatic islets underlies intrauterine hyperglycemia-induced glucose intolerance in offspring.
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Drug screening on tumor organoids exposes therapeutic vulnerabilities of meningiomas to HDAC1/2i panobinostat | Science Translational Medicine
The HDAC inhibitor panobinostat is effective against aggressive meningiomas, and resistance is mediated through a targetable HDAC8-TGFβ-EMT axis.
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Windshield wiper’s overlooked female inventor
Before cars and buses became ubiquitous features of the modern cityscape, many cities installed streetcars to shuttle…
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Stabilization of the H5 clade 2.3.4.4b hemagglutinin improves vaccine-elicited neutralizing antibody responses in mice | Science Translational Medicine
Vaccinating with a stabilized H5 hemagglutinin increases the proportion of humoral responses against neutralizing receptor binding site epitopes.
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A chemical ‘Goldilocks zone’ may limit which planets can host life
Astronomers’ favorite fable just got a new twist. The “Goldilocks zone” — the region of space not too close and not too far from a star where liquid water could exist on a planet’s surface — now has a chemical equivalent….
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Gut microbiome connected with heart disease precursor
Before the onset of cardiovascular disease symptoms, people often develop dyslipidemia, or abnormal levels of lipids in the blood. Recent studies suggest that microbes in the gut play an important role in how the body produces, regulates, and…
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Nitrous oxide, a product of fertilizer use, may harm some soil bacteria
Plant growth is supported by millions of tiny soil microbes competing and cooperating with each other as they perform important roles at the plant root, including improving access to nutrients and protecting against pathogens. As a byproduct of…
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