Mice
Unless noted otherwise, young female (8 weeks old) and male (4 weeks old) C57BL/6 mice were obtained from The Jackson Laboratory and old mice (18 months old) were acquired from the National Institute on Aging. For co-housing, mice were housed…
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Facile induction of immune tolerance by an interleukin-2–TGFβ surrogate agonist
Mice
Six-to-eight-week-old female and male C57BL/6 J mice (IMSR_JAX:000664), as well as other strains, were purchased from The Jackson Laboratory. OT-II (IMSR_JAX:004194) and Thy1.1 (IMSR_JAX:000406) mice were crossed to generate OT-II Thy1.1…
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Auto-crosslinking sporesilk fibers promote endospore and Cry toxin clustering
Aronson, A. I., Beckman, W. & Dunn, P. Bacillus thuringiensis and related insect pathogens. Microbiol. Rev. 50, 1–24 (1986).
Musso, D., Ko, A. I. & Baud, D. Zika virus infection—after the…
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A big-push community intervention reduced rates of child marriage by 80%
Child Marriage (UNICEF, 2022).
State of the Nigerian Girl Report: An Incisive Diagnosis of Child Marriage in Nigeria (Save the Children, 2021).
Asadullah, M. N. & Wahhaj, Z. Early marriage, social networks and the transmission of norms. Economica…
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B cell imprinting in children impairs antibodies to the haemagglutinin stalk
Human samples
Serum and peripheral blood mononuclear cell (PBMC) samples were obtained from participants enrolled in two prospective community-based studies in Nicaragua: The Household Influenza Transmission Study (HITS) and the Nicaraguan…
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A large-scale coherent 4D imaging sensor
Design and fabrication
Photonic device and circuit-level simulations were performed using ANSYS Lumerical tools, whereas the integrated electronics followed a design flow using Cadence Virtuoso.
The finalized design was verified against the design…
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Analysis of hybrid CNN models optimized with metaheuristic algorithms for melanoma detection
Rahman, Z., Hossain, M. S., Islam, M. R., Hasan, M. M. & Hridhee, R. A. An approach for multiclass skin lesion classification based on ensemble learning. Inform. Med. Unlocked 25, 100659 (2021).
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Ageing promotes metastasis via activation of the integrated stress response
Mice and in vivo studies
KrasLSL-G12D/+Trp53flox/flox mice (designated as KP)60 were maintained on a mixed C57BL/6-129/Sv genetic background. Lung tumours were induced in young KP (2–3 months old; referred to as KP-Young) and old KP…
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Snapshots of the dynamic basis of NTSR1 G protein subtype promiscuity
Expression and purification of G protein heterotrimer
G protein heterotrimer was expressed as described14 in Tni cells (Expression Systems; isolated from Trichoplusia ni; no validation or mycoplasma testing) with viruses for Gα, Gβγ and Ric-8a…
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Using mosquitoes to vaccinate bats could curb the spread of deadly diseases
Fruit bats carry Nipah virus, which has infected people in India and several other countries.Credit: C. K Thanseer/DeFodi images via Getty
Mosquitoes that have been designed to carry vaccines in their saliva have been used to inoculate bats…
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