Nature, Published online: 11 March 2026; doi:10.1038/d41586-026-00492-1
As mice age, changes in the microorganisms in their guts contribute to cognitive decline by altering signalling between the gut and brain.
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Gut microbes affect cognition during ageing
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The dynamic basis of G-protein recognition and activation by a GPCR
Hilger, D., Masureel, M. & Kobilka, B. K. Structure and dynamics of GPCR signaling complexes. Nat. Struct. Mol. Biol. 25, 4–12 (2018).
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B cell imprinting in children impairs antibodies to the haemagglutinin stalk
Human samples
Serum and peripheral blood mononuclear cell (PBMC) samples were obtained from participants enrolled in two prospective community-based studies in Nicaragua: The Household Influenza Transmission Study (HITS) and the Nicaraguan…
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Prototypical contrastive learning with patch-based spatio-temporal alignment for multivariate time series anomaly detection
Zheng, Y. et al. Correlation-aware spatial-temporal graph learning for multivariate time-series anomaly detection. IEEE Trans. Neural Netw. Learn. Syst. 35, 11802–11816 (2023).
Zhong, Z., Yu,…
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Facile induction of immune tolerance by an interleukin-2–TGFβ surrogate agonist
Mice
Six-to-eight-week-old female and male C57BL/6 J mice (IMSR_JAX:000664), as well as other strains, were purchased from The Jackson Laboratory. OT-II (IMSR_JAX:004194) and Thy1.1 (IMSR_JAX:000406) mice were crossed to generate OT-II Thy1.1…
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A big-push community intervention reduced rates of child marriage by 80%
Child Marriage (UNICEF, 2022).
State of the Nigerian Girl Report: An Incisive Diagnosis of Child Marriage in Nigeria (Save the Children, 2021).
Asadullah, M. N. & Wahhaj, Z. Early marriage, social networks and the transmission of norms. Economica…
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Optical pumping effect on modulation transfer spectroscopy of the $$D_1$$ line of $$^{85}$$ Rb atoms with non-cycling transition
Khan, S. et al. Theoretical and experimental study of modulation transfer spectroscopy for non-cycling transitions of Rb D\(_1\) lines. J. Quant. Spectrosc. Radiat. Transf. 322, 109037 (2024).
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Auto-crosslinking sporesilk fibers promote endospore and Cry toxin clustering
Aronson, A. I., Beckman, W. & Dunn, P. Bacillus thuringiensis and related insect pathogens. Microbiol. Rev. 50, 1–24 (1986).
Musso, D., Ko, A. I. & Baud, D. Zika virus infection—after the…
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Ageing promotes metastasis via activation of the integrated stress response
Mice and in vivo studies
KrasLSL-G12D/+Trp53flox/flox mice (designated as KP)60 were maintained on a mixed C57BL/6-129/Sv genetic background. Lung tumours were induced in young KP (2–3 months old; referred to as KP-Young) and old KP…
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Dynamics of circulating tumour DNA can guide treatment decisions for improved outcomes
- CLINICAL BRIEFINGS
A phase II trial shows that the risk of cancer…
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