Clinical profile of the patient cohort
A total of 31 patients (6 males [19.4%] and 25 females [80.6%]; mean age 67.7 years, range 48–83 years, standard deviation ± 8.31 years) with clinically, radiologically, and histologically confirmed…
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Abundance-biased codon diversification prevents recombination in AAV production and ensures robust in vivo expression of functional FRET sensors
Cloning
The codon-diversified sequences for cdCitrine(M20) and cdcp173tdVenus(M15) were custom-synthesized (ThermoFisher GeneArt) with inclusion of terminal or linking stretches containing restriction sites for insertion in plasmids for viral…
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The origin of hypervelocity white dwarfs in the merger disruption of He–C–O white dwarfs
Jordan, G. C., Perets, H. B., Fisher, R. T. & van Rossum, D. R. Failed-detonation supernovae: subluminous low-velocity Ia supernovae and their kicked remnant white dwarfs with iron-rich cores. Astrophys. J. Lett. 761, L23 (2012).
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Evolution of claudin18.2 therapies in gastroesophageal cancers
Competing interests
S.J.K. has served a consultant/advisory role for Bristol Myers Squibb, Merck, Astellas, Daiichi-Sankyo, Natera, Novartis, AstraZeneca, Mersana, Beigene, Gilead, Elevation Oncology,…
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Signatures of magnetism in zigzag graphene nanoribbons embedded in a hexagonal boron nitride lattice
Nakada, K., Fujita, M., Dresselhaus, G. & Dresselhaus, M. S. Edge state in graphene ribbons: nanometer size effect and edge shape dependence. Phys. Rev. B 54, 17954–17961 (1996).
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Reduced IFN-γ-expressing SARS-CoV-2 specific CD4+ T cells and transient CD8 + T cell activation associate with higher HOMA-IR 1-year post COVID-19 in obese individuals
Study population
This study is a post hoc exploratory analysis conducted using data from the previously registered and published CARAMEL study (NCT04802044)16. It examined a subgroup of 47 participants (31 males and 16 females) with a mean age of…
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Application of virtual assembly for complex mechanical structures based on digital twin technology
Fig. 1 Construction process of complex mechanical virtual assembly.
In the virtual assembly process of complex mechanical structures, hierarchical modeling is a crucial task. This process aims to achieve a comprehensive and precise mapping of…
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In situ structure determination of conformationally flexible targets using nextPYP
Lucas, B. A. et al. Locating macromolecular assemblies in cells by 2D template matching with cisTEM. eLife 10, e68946 (2021).
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Cheng, J. et al. Determining…
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Emerging frontiers in two-dimensional sliding ferroelectrics
Noncentrosymmetric Crystal Phases
Taking the most extensively studied MoS2 as an example, its 3 R, 1 T, 1 T, 1 T”, and 1 T” phases all belong to non-centrosymmetric structural configurations, among which the 3 R and 1 T” phases…
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Is collapsing fertility really the end of the world?
In 1970, a woman in Mexico might have expected to have seven children, on average. By 2014, that figure had fallen to around two. As of 2023, it was just 1.6. That means that the population is no longer making enough babies to maintain…
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