In everyday life, one must deal with obscure and complicated information to reach a firm conclusion. The crisp set theory only deals with the MD of an element in the form of \(0\) or \(1,\) but falls short when dealing with MD somewhere between 0…
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With the flip of a membrane protein
γ-Glutamyl carboxylase (GGCX) is a transmembrane protein localized on the endoplasmic reticulum membrane that catalyzes vitamin K-dependent carboxylation of glutamate and aspartate residues in endoplasmic reticulum lumen proteins. Okazaki et al….
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Noncanonical function of Pannexin1 promotes cellular senescence and renal fibrosis post-acute kidney injury
Mice and AKI-CKD murine model
This study used male C57BL/6 mice that were 8–12 weeks old and weighed 20–25 g. Only male mice were used to minimize potential experimental variability arising from the hormonal fluctuations of the female…
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Impairment in the behavioral control of body sway, gaze shift, and mental workload in Parkinson’s disease
Participants
Nineteen PD patients and 20 healthy age-matched controls participated in the study. This sample size was considered to be sufficient. Indeed, in a one-tailed test in G*Power (G*Power software, version 3.1.9.2; Düsseldorf, Germany), an…
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African countries must rethink health-care financing
Health-care systems in Africa have conventionally relied heavily on donations and support from other countries. A reduction in such funding — of around 70% between 2021 and 2025 — poses a substantial threat to Africa’s health-care system,…
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Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment
Animal models
The following mouse lines were used: C57BL/6J mice (The Jackson Laboratory, line 000664), C57BL/6 aged mice (National Institutes of Aging) and B6;129-Gt(ROSA)26Sortm1(CAG-cas9*,-EGFP)Fezh/J (The Jackson Laboratory, line 024857). All…
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The impact of stator module gaps on the performance of canned permanent magnet synchronous motors with segmented stators
To ensure that the motor operates within a safe temperature range, it is necessary to maintain a constant input current to the motor. Therefore, with the input current constant, the proposed ICM method and FEM were used to analyze the impact of…
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Application of virtual assembly for complex mechanical structures based on digital twin technology
Fig. 1 Construction process of complex mechanical virtual assembly.
In the virtual assembly process of complex mechanical structures, hierarchical modeling is a crucial task. This process aims to achieve a comprehensive and precise mapping of…
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A new glycosylated derivative of rausuquinone with cytotoxic activity from Streptomyces sp. HU061-2
A new glycosylated derivative of rausuquinone, rausuquinonoside (1), was isolated from the Tai Lake sediment-derived actinomycete, Streptomyces sp. HU061-2. The structure of 1 was determined by 1D, 2D NMR, MS spectral analysis and the comparison…
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Machine learning based screening of biomarkers associated with cell death and immunosuppression of multiple life stages sepsis populations
Aziz, M. et al. B-1a cells protect mice from sepsis-induced acute lung injury. Mol. Med. 24(1), 26 (2018).
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Bowdish, M. E. et al. A randomized trial of…
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