Over the past 5 years, an increase in the affordability of genomic sequencing technologies, paired with the advancement of computational tools to assess genomic data, has made generating molecular insights into drivers of biodiversity more…
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O-GlcNAc transferase plays dual antiviral roles by integrating innate immunity and lipid metabolism
Ablasser, A. & Hur, S. Regulation of cGAS- and RLR-mediated immunity to nucleic acids. Nat. Immunol. 21, 17–29 (2020).
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Brubaker, S. W., Bonham, K. S., Zanoni, I. & Kagan, J. C….
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University english teaching evaluation using artificial intelligence and data mining technology
Research background and motivations
In higher education, English teaching is considered a crucial subject, and its teaching quality and assessment effectiveness have always been a focus of attention1,2,3. Traditional methods for evaluating English…
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A new fossil plesiomorphic flat bug (Aradidae) suggests widespread flower visiting in Heteroptera during the Mesozoic
Benton, M. J., Wilf, P. & Sauquet, H. The angiosperm terrestrial revolution and the origins of modern biodiversity. New. Phytol. 233, 2017–2035 (2022).
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Peris, D. & Condamine, F….
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Laurel–Yanny percept affects the speech-to-song illusion, but musical anhedonia does not
The song illusion influences the effect of phrase repetition on liking
Figure 1 shows the overall average musicality and liking ratings before and after repetition separately for control and illusion stimuli. Across our entire sample…
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TrimNN: characterizing cellular community motifs for studying multicellular topological organization in complex tissues
Problem setting
Formally, we define the triangulated graph \(G\) as the CC inferred from spatial omics using Delaunay triangulation13, where \(G=\{V,E\}\) with \(\left|V\right|=n\) nodes and \(\left|E\right|\) edges. The size-\(k\) CC motif is a…
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FGF15/FGFR4 signaling suppresses M1 macrophage polarization and multi-organ inflammation in septic mice by inhibiting H3K18 lactylation-driven Irf7 expression through NF2-Hippo activation
Animals
Male C57BL/6 mice (7–8-week old, weighing 18–22 g) were purchased from Hunan Slake Jingda Experimental Animal Co., Ltd. (Changsha, China). The animals were acclimated for one week in a specific pathogen-free (SPF) environment,…
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Include Indigenous Knowledge systems in climate reports
Indigenous peoples’ knowledge of the natural environment holds value for climate-change monitoring, adaptation, science and policy. The Intergovernmental Panel on Climate Change (IPCC) reports — often seen as definitive assessments of climate…
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MOFI-FL, a novel score for detecting hepatic steatosis and predicting cardiometabolic mortality
Targher, G., Tilg, H. & Byrne, C. D. Non-alcoholic fatty liver disease: a multisystem disease requiring a multidisciplinary and holistic approach. Lancet Gastroenterol. Hepatol. 6 (7), 578–588 (2021).
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Educational attainment in sociocentric networks associates with cardiac biomarkers in Korean elders
Study design and participants
We used a part of the prospective cohort data obtained from the Korean Social Life, Health and Aging Project (KSHAP), which was collected across three waves: wave 1 (2011), wave 4 (2015–2016), and wave 5…
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