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  • FGF15/FGFR4 signaling suppresses M1 macrophage polarization and multi-organ inflammation in septic mice by inhibiting H3K18 lactylation-driven Irf7 expression through NF2-Hippo activation

    FGF15/FGFR4 signaling suppresses M1 macrophage polarization and multi-organ inflammation in septic mice by inhibiting H3K18 lactylation-driven Irf7 expression through NF2-Hippo activation

    Animals

    Male C57BL/6 mice (7–8-week old, weighing 18–22 g) were purchased from Hunan Slake Jingda Experimental Animal Co., Ltd. (Changsha, China). The animals were acclimated for one week in a specific pathogen-free (SPF) environment,…

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  • Dynamic cerebral autoregulation during and 3 months after endovascular treatment in large vessel occlusion stroke

    Dynamic cerebral autoregulation during and 3 months after endovascular treatment in large vessel occlusion stroke

    Baseline characteristics

    Baseline information and medical history of all enrolled subjects and grouped into subjects with and without in-person 90-day FU are listed in Table 1 and Supplementary Table S5. No differences between the FU and non-FU…

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