In a talk given I enjoyed at the 74th Lindau Nobel Laureate meeting in early July, Akira Yoshino said that he feels he has a duty as a Nobel prize winner to inspire hope in future generations of scientists. To do so, every year he makes a…
Category: 6. Chemistry
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InSilico’s rentosertib could become first AI-designed drug to reach phase 3 trials and change drug discovery forever
No drug designed by artificial intelligence has ever entered a phase 3 clinical trial, the final hurdle before regulatory approval. This could soon change, however. A small molecule from InSilico Medicine that targets a chronic lung disease could…
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Learning about chemistry in prenatal class | Opinion
Things are about to change in the Motion household – we’re welcoming our first baby soon and excitedly preparing for their arrival. Frankie, our beautiful five-year-old dog, knows that’s something is up. She’s moulding herself even…
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New synthetic strategy using gem-dichlorides creates diverse carbenes for cyclopropane synthesis without explosive diazo reagents
A new synthetic strategy can catalytically access all carbene polarities with one mechanism. This mild and tuneable method reduces the complexity of forming certain cyclopropanes and offers opportunities for click-like reactions in chemical…
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Synthesis and in silico studies of new thiophene-isoquinolinone hybrids as potential larvicides against Culex pipiens
Chemistry
All melting points were measured on a Griffin and George melting-point apparatus (Griffin & Georgy Ltd., Wembley, Middlesex, UK) and are uncorrected. IR spectra were recorded on Pye Unicam SP1200 spectrophotometer (Pye Unicam Ltd.,…
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Optimization of separation and purification processes in diethyl ether production for improved efficiency and sustainability
In previous study, the ethanol dehydration reaction was simulated and optimized from both technical and economic perspectives30. In the current study, the process was first run based on the reactor optimum conditions obtained in the previous…
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A highly chemo- and regioselective synthesis of heterocyclic [3.3.3]propellanes via sequential multicomponent reactions in water
General remarks
The chemicals utilized in the experiments, including malononitrile, ninhydrin, 1,1-bis(methylthio)-2-nitroethane, ethylenediamine, diaminopropane, 1,4-butanediamine and N-methyl-1-(thiomethyl)-2-nitroethanamine, as well as the…
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Harnessing the power of S/N-doped NiO nanoparticles through bandgap tuning to achieve enhanced photocatalytic and antibacterial performances
Detailed descriptions of the materials and experimental procedures used in this study are available in the Supporting Information. A schematic illustration of the synthesis process is presented as Fig. S1 (supplementary information)….
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Analytical strategies for identification and quantitation of heterodimers in co-formulated monoclonal antibody cocktails by native SEC-MS
Quantitative performance of nSEC-UV/MS method using an MS-compatible mobile phase
SEC separates biomolecules based on their hydrodynamic radii. When coupled with UV detection, SEC-UV analysis is widely used as a quality control (QC) method to…
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‘It is so important that the people who make up that committee are not political puppets’ | News
Last month, UN member states signed off on an agreement to launch a new panel to advise on chemicals, waste and pollution. The UN Environment Programme (UNEP) says that the panel will complete ‘a global scientific trifecta’ alongside the…
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