A natural citrus oil from oranges, lemons, and limes is proving highly effective in relieving dry mouth, and when combined with a new lipid formulation, new research suggests it may be effective without significant side…
Category: 5. Biology
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48% Depression Diagnoses are Treatment-resistant
Almost half of people with depression meet criteria for being ‘treatment-resistant’, found a new study published in the British Journal of Psychiatry.
Definitions for treatment-resistant depression vary….
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RNA function follows form – why is it so hard to predict?
RNA structure poses unique challenges for computational models.Credit: Getty
At a virtual conference in November 2020, the winner of a biennial protein-structure-prediction challenge was announced: AlphaFold. Created by Google DeepMind, this…
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Non-viral generation of transgenic non-human primates via the piggyBac transposon system
Ethical statement
We followed the Reporting in Vivo Experiments (ARRIVE) guidelines developed by the National Centre for the Replacement, Refinement & Reduction of Animals in Research (NC3Rs). We also followed “The Act on Welfare and Management…
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Exploiting HLA-DR mismatches for CAR therapy in acute myeloid leukemia
Thol, F., Dohner, H. & Ganser, A. Blood 143, 11–20 (2024).
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Brudno, J. N., Maus, M. V. & Hinrichs, C. S. JAMA 332, 1924–1935 (2024).
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An organelle-agnostic image analysis tool
While state-of-the-art microscopy analysis tools are quickly improving our capability to visualize and understand intracellular dynamics, they still suffer from many limitations. For instance, existing tools are often specialized to specific…
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Jaw1 accelerates the reaction speed of the Ca2+ signals via ITPRs upon GPCR stimulation
Our previous work demonstrated that Jaw1 enhances the Ca2+ release activity of ITPRs upon GPCR stimulation, particularly in terms of the maximum amplitude and retention time13,22. Importantly, these effects vary depending on the ITPR subtype. In…
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Pharmacological and resting state fMRI reveal Osteocalcin’s effects on mouse brain regions with high Gpr37 and Gpr158 expression
Study design
The objective of this study was to examine the effects of intravenously injected OCN on the wild-type mouse brain by multiparametric MRI. Female C57BL/6J mice (n = 32) were randomly divided into a control group that received…
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A contextualized ecological theory | Nature Reviews Biodiversity
The field of ecology is increasingly occupied with reconciling the structure of ecosystems with their functions: for example, trying to accurately predict the rate at which nutrients cycle through (or accumulate within) an ecosystem from the…
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Epigenetic editing at individual age-associated CpGs affects the genome-wide epigenetic aging landscape
CRISPR-guided epigenetic editing is site specific and stable
Initially, we aimed to modify DNAm in a genomic region within phosphodiesterase 4C (PDE4C), which was identified as one of the first sites to gain age-associated DNAm across different…
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