Category: 5. Biology

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  • An organelle-agnostic image analysis tool

    While state-of-the-art microscopy analysis tools are quickly improving our capability to visualize and understand intracellular dynamics, they still suffer from many limitations. For instance, existing tools are often specialized to specific…

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  • Jaw1 accelerates the reaction speed of the Ca2+ signals via ITPRs upon GPCR stimulation

    Jaw1 accelerates the reaction speed of the Ca2+ signals via ITPRs upon GPCR stimulation

    Our previous work demonstrated that Jaw1 enhances the Ca2+ release activity of ITPRs upon GPCR stimulation, particularly in terms of the maximum amplitude and retention time13,22. Importantly, these effects vary depending on the ITPR subtype. In…

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  • Pharmacological and resting state fMRI reveal Osteocalcin’s effects on mouse brain regions with high Gpr37 and Gpr158 expression

    Pharmacological and resting state fMRI reveal Osteocalcin’s effects on mouse brain regions with high Gpr37 and Gpr158 expression

    Study design

    The objective of this study was to examine the effects of intravenously injected OCN on the wild-type mouse brain by multiparametric MRI. Female C57BL/6J mice (n = 32) were randomly divided into a control group that received…

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