A team of biologists at Queen Mary University of London has discovered that a neurohormone controlling appetite in humans has an ancient evolutionary origin, dating back over half a billion years. The findings, published in…
Category: 5. Biology
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New chromatin tracing method unlocks DNA looping process in high resolution
Among the many marvels of life is the cell’s ability to divide and thus enable organisms to grow and renew themselves. For this, the cell must duplicate its DNA – its genome – and segregate it equally into two new daughter…
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Inhibiting hedgehog signal by a patched-1 antibody
The Hedgehog (HH) signaling pathway is crucial for the developmental patterning of animal embryogenesis and the regeneration of adult tissues1. The aberrant activation of HH signaling has been linked…
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Kinetically activating nanovaccine mimicking multidimensional immunomodulation of natural infection for broad protection against heterologous viruses in animal models
Materials and reagents
Alhydrogel adjuvant 2% (alum, cat. no. vac-alu-50) and Adju-Phos adjuvant (AdjuPhos, cat. no. vac-phos-250) were purchased from InvivoGen (San Diego, CA, USA). Ovalbumin from chicken egg white (OVA, cat. no. A5503) and…
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A Csde1-Strap complex regulates plasma cell differentiation by coupling mRNA translation and decay
Identification of differentiation stage-specific RBPomes via mRNA-interactome capture
We performed mRNA interactome capture (RIC) to identify RBPs expressed at different stages of plasma cell differentiation in an in vitro culture system mimicking…
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Enzymatic cleavage of model lignin dimers depends on pH, enzyme, and bond type
Enzyme activity screening
pH is hypothesized to be one of the most important conditions for enzymatic depolymerization of lignin polymers. pH influences the degree of polymerization versus depolymerization by LMEs24and developing LMEs that…
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Deciphering genetic causality between plasma BDNF and 91 circulating inflammatory proteins through bidirectional mendelian randomization
Leschik, J. et al. Brain-derived neurotrophic factor expression in serotonergic neurons improves stress resilience and promotes adult hippocampal neurogenesis. Prog Neurobiol. 217, 102333. https://doi.org/10.1016/j.pneurobio.2022.102333 (2022).
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Small-molecule glues selectively restrict deubiquitylase activity and inflammatory signaling
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E.Z. and F.C. used ChatGPT to help prepare their contribution to this Research Briefing.
This is a summary of:…
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Characterization of pritumumab in murine models and primate safety study
Cell lines
All cell lines were obtained and used as previously described18. The U251-MG cell line was purchased from Sigma Aldrich (St. Louis, MO). PANC-1, SF188, A549 cells used were purchased from the American Type Culture Collection (ATCC,…
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IoT powered RNN for improved human activity recognition with enhanced localization and classification
Javeed, M. et al. Physical human locomotion prediction using manifold regularization. Peer J. Comput. Sci. 8, 1105 (2022).
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Javeed, M., Mudawi, N., Alabduallah, B.,…
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