These authors contributed equally: Alicia Huerta-Chagoya, Philip Schroeder, Ravi Mandla, Jiang Li.
These authors jointly supervised this work: Uyenlinh L. Mirshahi, Alisa K. Manning, Aaron Leong, Miriam Udler, Josep M. Mercader.
Programs in…
Category: 5. Biology
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Reply to: About proteins of a siphophage tail tip complex reverting to their pre-ejection fold after DNA ejection
replying to C. A. Arnaud et al. Nature Communications https://doi.org/10.1038/s41467-025-57874-8 (2025)
In a recent Matters Arising, Arnaud et al. critically reviewed our recent work on the structure…
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Dynamic synthesis and transport of phenazine-1-carboxylic acid to boost extracellular electron transfer rate
Construction and optimization of the PCA biosynthesis pathway in S. oneidensis
Using S. oneidensis MR-1, we found that the addition of PCA at ~80 µM resulted in the highest power generation, which was significantly…
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Inhibiting hedgehog signal by a patched-1 antibody
The Hedgehog (HH) signaling pathway is crucial for the developmental patterning of animal embryogenesis and the regeneration of adult tissues1. The aberrant activation of HH signaling has been linked…
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Kinetically activating nanovaccine mimicking multidimensional immunomodulation of natural infection for broad protection against heterologous viruses in animal models
Materials and reagents
Alhydrogel adjuvant 2% (alum, cat. no. vac-alu-50) and Adju-Phos adjuvant (AdjuPhos, cat. no. vac-phos-250) were purchased from InvivoGen (San Diego, CA, USA). Ovalbumin from chicken egg white (OVA, cat. no. A5503) and…
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A Csde1-Strap complex regulates plasma cell differentiation by coupling mRNA translation and decay
Identification of differentiation stage-specific RBPomes via mRNA-interactome capture
We performed mRNA interactome capture (RIC) to identify RBPs expressed at different stages of plasma cell differentiation in an in vitro culture system mimicking…
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Enzymatic cleavage of model lignin dimers depends on pH, enzyme, and bond type
Enzyme activity screening
pH is hypothesized to be one of the most important conditions for enzymatic depolymerization of lignin polymers. pH influences the degree of polymerization versus depolymerization by LMEs24and developing LMEs that…
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Deciphering genetic causality between plasma BDNF and 91 circulating inflammatory proteins through bidirectional mendelian randomization
Leschik, J. et al. Brain-derived neurotrophic factor expression in serotonergic neurons improves stress resilience and promotes adult hippocampal neurogenesis. Prog Neurobiol. 217, 102333. https://doi.org/10.1016/j.pneurobio.2022.102333 (2022).
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Small-molecule glues selectively restrict deubiquitylase activity and inflammatory signaling
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
E.Z. and F.C. used ChatGPT to help prepare their contribution to this Research Briefing.
This is a summary of:…
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Characterization of pritumumab in murine models and primate safety study
Cell lines
All cell lines were obtained and used as previously described18. The U251-MG cell line was purchased from Sigma Aldrich (St. Louis, MO). PANC-1, SF188, A549 cells used were purchased from the American Type Culture Collection (ATCC,…
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