Ethical statement
We followed the Reporting in Vivo Experiments (ARRIVE) guidelines developed by the National Centre for the Replacement, Refinement & Reduction of Animals in Research (NC3Rs). We also followed “The Act on Welfare and Management…
Category: 5. Biology
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Exploiting HLA-DR mismatches for CAR therapy in acute myeloid leukemia
Thol, F., Dohner, H. & Ganser, A. Blood 143, 11–20 (2024).
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Brudno, J. N., Maus, M. V. & Hinrichs, C. S. JAMA 332, 1924–1935 (2024).
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An organelle-agnostic image analysis tool
While state-of-the-art microscopy analysis tools are quickly improving our capability to visualize and understand intracellular dynamics, they still suffer from many limitations. For instance, existing tools are often specialized to specific…
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Jaw1 accelerates the reaction speed of the Ca2+ signals via ITPRs upon GPCR stimulation
Our previous work demonstrated that Jaw1 enhances the Ca2+ release activity of ITPRs upon GPCR stimulation, particularly in terms of the maximum amplitude and retention time13,22. Importantly, these effects vary depending on the ITPR subtype. In…
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Pharmacological and resting state fMRI reveal Osteocalcin’s effects on mouse brain regions with high Gpr37 and Gpr158 expression
Study design
The objective of this study was to examine the effects of intravenously injected OCN on the wild-type mouse brain by multiparametric MRI. Female C57BL/6J mice (n = 32) were randomly divided into a control group that received…
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A contextualized ecological theory | Nature Reviews Biodiversity
The field of ecology is increasingly occupied with reconciling the structure of ecosystems with their functions: for example, trying to accurately predict the rate at which nutrients cycle through (or accumulate within) an ecosystem from the…
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Epigenetic editing at individual age-associated CpGs affects the genome-wide epigenetic aging landscape
CRISPR-guided epigenetic editing is site specific and stable
Initially, we aimed to modify DNAm in a genomic region within phosphodiesterase 4C (PDE4C), which was identified as one of the first sites to gain age-associated DNAm across different…
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A novel anti-obesity peptide that targets the hypothalamus
Computational tools that predict which amino acid sequences are produced by cleavage enzymes can accelerate the discovery of bioactive peptides with therapeutic potential. A study recently published in Nature presents a peptide prediction…
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A High-Fat Diet Weakens Immunity in a Mouse Model
Obesity rates have been steadily rising around the world for many years. Obesity has been linked to a variety of health problems including metabolic disorders such as type 2 diabetes and cardiovascular…
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Chinese Blackbirds Are Mimicking Electric Moped Alarms
Chinese Blackbirds can mimic electric moped alarms, though their imitations are simplified. A new study shows this mimicry is more common than expected and may involve copying both the source and other birds, prompting further research into urban…
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