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Category: 5. Biology
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MFSD6 is an entry receptor for enterovirus D68
With the near eradication of poliovirus due to global vaccination campaigns, attention has shifted to other enteroviruses that can cause polio-like paralysis syndrome (now termed acute flaccid myelitis (AFM))1–3. In particular, enterovirus D68…
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Immunologic correlates in a CIC::DUX4 fusion-positive sarcoma responsive to dual immune checkpoint blockade
This report presents evidence that dual ICB with nivolumab and relatlimab can induce a robust antitumor immune response in CDS. The patient described here remains alive more than 24 months following diagnosis with metastatic disease, with a…
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Characterizing the tumor suppressor activity of FLCN in Birt-Hogg-Dubé syndrome cell models through transcriptomic and proteomic analysis
Birt AR, Hogg GR, Dubé WJ. Hereditary multiple fibrofolliculomas with trichodiscomas and acrochordons. Arch Dermatol. 1977;113:1674–7.
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Schmidt LS, Linehan WM. Molecular…
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Connexin 43 is downregulated in advanced Parkinson’s disease in multiple brain regions which correlates with symptoms
Okunoye, O., Marston, L., Walters, K. & Schrag, A. Change in the incidence of Parkinson’s disease in a large UK primary care database. NPJ Park. Dis. 8, 1–7 (2022).
Parkinson’s_UK. The…
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A novel in-vitro expression assay by LC/MS/MS enables multi-antigen mRNA vaccine characterization
IVE-LC/MS/MS synopsis
The in-vitro expression-liquid chromatography mass spectrometry (IVE-LC/MS/MS) method is fundamentally a PRM method, in which the analytes are select peptides unique to the expressed target protein antigens. The well…
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Transcriptomic profiling of blood platelets identifies a diagnostic signature for pancreatic cancer
Ilic M, Ilic I. Epidemiology of pancreatic cancer. World J Gastroenterol. 2016;22:9694–705.
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Amundadottir L, Kraft P, Stolzenberg-Solomon RZ, Fuchs CS, Petersen…
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Computational drug design for neurosyphilis disease by targeting Phosphoglycerate Kinase in Treponema pallidum with enhanced binding affinity and reduced toxicity
Structure retrieval of the target protein
The 3D structures were retrieved from three tools: I-TASSER, Robetta, and AlphaFold. Among these, the AlphaFold structure was selected ID (B2S3D0). The alignment graph from Alphafold represents the…
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Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors
Next-day reporting of molecular diagnostic results
After a proof-of-concept preliminary version19, Rapid-CNS2 was run independently at two centers on fresh or cryopreserved tumor tissue (University Hospital Heidelberg, Germany and University of…
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