Ambenonium effect on 3CLpro
Enzymes have long been recognized as excellent drug targets. Almost half of all clinically used oral drugs target an enzyme39, and many drugs in big pharma companies’ portfolios target an…
Category: 5. Biology
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In vitro enzymatic and cell culture assays for SARS-CoV-2 main protease interaction with ambenonium
Ambenonium effect on 3CLpro
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Novel dual action chimera doxorubizen demonstrates superior efficacy to doxorubicin in acute leukemia
The starting drug (doxorubicin, SN-38, lenalidomide, etoposide, combretastatin, 5-fluorouracil, 6-mercaptopurine, riluzole; 50 mg, 1 equiv. each) was dissolved in dry DMF (5 mL) under a nitrogen atmosphere, and the reaction…
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Heritability and polygenic load for comorbid anxiety and depression
Sample characteristics
All regression models were based on complete cases. Data on drug prescription were retrieved for 13699 individuals, where genotype information was available for 12792 participants (see Table 1 for sample characteristics)….
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Molecular basis of the functional conflict between chloroquine and peptide transport in the Malaria parasite chloroquine resistance transporter PfCRT
Chloroquine’s access to the cavity recapitulates expected PfCRT isoform relationships
The CQ-sensitive wild-type (3D7) parasites are unable to evade the toxic effects of CQ because 3D7-PfCRT is unable to transport the drug in sufficient amounts…
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Imaging and spatially resolved mass spectrometry applications in nephrology
Chen, S. et al. Analysis of cell glycogen with quantitation and determination of branching using liquid chromatography–mass spectrometry. Anal. Chem. 95, 12884–12892 (2023).
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Exploring the polygenic landscape of wool traits in Turkish Merinos through multi-locus GWAS approaches: middle Anatolian Merino
The data on FD and SL reveal different patterns of heritability and variability. FD shows moderately high heritability (h2 = 0.461) but low variability (CV = 7.570%), suggesting that while genetic factors significantly influence this…
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Deep immune cell profiling in blood and bone marrow of early stage monoclonal gammopathy: an iStopMM and ECRIN-M3 collaborative study
Increasing evidences support a key role of the immune system in the development and progression of monoclonal gammopathies (MG), i.e., from premalignant stages—e.g., MG of undetermined significance…
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Inducible transposon mutagenesis identifies bacterial fitness determinants during infection in mice
Van Opijnen, T., Bodi, K. L. & Camilli, A. Tn-seq: high-throughput parallel sequencing for fitness and genetic interaction studies in microorganisms. Nat. Methods 6, 767–772 (2009).
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Early stage of metabolic dysfunction associated steatotic liver disease disrupts circadian rhythm and induces neuroinflammation in rats
HFHC diet triggers gradual MASLD development characterised by mild liver and metabolic alteration
Impact of HFHC diet on body weight, liver and visceral fat
At the end of the 30-day diet, the average weight of the HFHC group was significantly below…
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Early antiviral type I interferon impairs lung metastasis
Invasive breast cancer is a leading cause of cancer-related death among women. Metastatic spread of breast cancer to the lungs is common and is associated with markedly decreased lifespan. The immunosuppressive environment of cancer can increase…
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