Scientists in Basel revealed that energy-producing proteins in mitochondria form large supercomplexes, boosting ATP production efficiency and offering new insights into cell biology, evolution, and disease. Mitochondria, often called the…
Category: 5. Biology
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Scientists Reveal Hidden Machinery of Mitochondria in Stunning Detail
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How individual variation shapes ecological niches in two Pipistrellus bat species
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Origin and function of beneficial bacterial symbioses in insects
Drew, G. C., Stevens, E. J. & King, K. C. Microbial evolution and transitions along the parasite–mutualist continuum. Nat. Rev. Microbiol. 19, 623–638 (2021).
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Deciphering permissivity of human tumor ecosystems to oncolytic viruses
Korman AJ, Garrett-Thomson SC, Lonberg N. The foundations of immune checkpoint blockade and the ipilimumab approval decennial. Nat Rev Drug Discov. 2022;21:509–28.
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Paul J,…
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Independent origins and non-parallel selection signatures of triclabendazole resistance in Fasciola hepatica
Furst, T., Duthaler, U., Sripa, B., Utzinger, J. & Keiser, J. Trematode infections: liver and lung flukes. Infect. Dis. Clin. North Am. 26, 399–419 (2012).
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Keratin-72 restricts HIV-1 infection in resting CD4+ T cells by sequestering capsids in intermediate filaments
KRT72 is a partner of Vpxrcm that is specifically expressed in resting CD4+ T cells
As Vpxrcm and Vpxmnd-2 overcome a SAMHD1-independent block to improve HIV-1 RT in early-phase HIV-1 replication in resting CD4+ T cells21, the objective was to…
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In vitro enzymatic and cell culture assays for SARS-CoV-2 main protease interaction with ambenonium
Ambenonium effect on 3CLpro
Enzymes have long been recognized as excellent drug targets. Almost half of all clinically used oral drugs target an enzyme39, and many drugs in big pharma companies’ portfolios target an…
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Novel dual action chimera doxorubizen demonstrates superior efficacy to doxorubicin in acute leukemia
The starting drug (doxorubicin, SN-38, lenalidomide, etoposide, combretastatin, 5-fluorouracil, 6-mercaptopurine, riluzole; 50 mg, 1 equiv. each) was dissolved in dry DMF (5 mL) under a nitrogen atmosphere, and the reaction…
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Heritability and polygenic load for comorbid anxiety and depression
Sample characteristics
All regression models were based on complete cases. Data on drug prescription were retrieved for 13699 individuals, where genotype information was available for 12792 participants (see Table 1 for sample characteristics)….
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Molecular basis of the functional conflict between chloroquine and peptide transport in the Malaria parasite chloroquine resistance transporter PfCRT
Chloroquine’s access to the cavity recapitulates expected PfCRT isoform relationships
The CQ-sensitive wild-type (3D7) parasites are unable to evade the toxic effects of CQ because 3D7-PfCRT is unable to transport the drug in sufficient amounts…
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