Glaucoma is a neurodegenerative disease characterized by increased intraocular pressure (IOP), ultimately leading to optic nerve damage and irreversible vision loss. IOP is primarily regulated by the conventional outflow tract — consisting of…
Category: 5. Biology
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In vitro and in silico pharmacological effects of Rosmarinus officinalis leaf methanolic extracts and essential oils
Akacha, B. B. et al. Recent advances in phytochemistry, pharmaceutical, biomedical, phytoremediation, and bio-preservative applications of Lobularia maritima. S. Afr. J. Bot. 165, 202–216 (2024).
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OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide
Schübeler, D. Function and information content of DNA methylation. Nature 517, 321–326 (2015).
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Meissner, A. DNA methylation: a historical perspective. Trends…
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Post-transcriptional modular synthetic receptors | Nature Chemical Biology
Manhas, J., Edelstein, H. I., Leonard, J. N. & Morsut, L. The evolution of synthetic receptor systems. Nat. Chem. Biol. 18, 244–255 (2022).
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Carbohydrate intake and activation of gastric acid secretion decrease gastric estrogen secretion
Blood Estrogen decreases after meals, especially after carbohydrate intake in males
First, we examined the changes in blood estrogen levels after feeding a high-fat diet (HFD) and a normal diet (ND). Rats fed HFD were given a week to adapt to the…
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CXCL7 promotes bone erosion in RA
Bone destruction is a hallmark feature of rheumatoid arthritis (RA), and individuals with anti-citrullinated protein antibody (ACPA)-positive RA tend to experience worse bone erosion than those with ACPA-negative RA. Chemokines, such as CXCL7,…
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Type III interferon primes pDCs for TLR7 activation and antagonizes immune suppression mediated by TGF-β and PGE2
Human samples and study approval
Healthy human blood (collected in EDTA anticoagulant-containing tubes) was purchased anonymously from the Etablissement Français du Sang (EFS, Lyon, France). Participants were French voluntary donors, not…
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Programmed enhancement of endogenous iron-mediated lysosomal membrane permeabilization for tumor ferroptosis/pyroptosis dual-induction
Synthesis and Characterization of UCNP-Cro/FA
First, the croconaine molecules containing carboxyl groups (denoted as Cro) were synthesized following the procedure shown in Supplementary Fig. 1. The chemical structures of the intermediates and Cro…
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Transcriptional signature of rapidly responding NK cells reveals S1P5 and CXCR4 as anti-tumor response disruptors
Fig. 1 LAMP1 is detected at the cell surface of stimulated NK cells and can be modulated by IL-2 and TGF-β. In all instances, NK cells were treated for 48 h with the indicated cytokine regimens (IL-2 20 ng/mL, TGF-β 10 ng/mL or vehicle). For…
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