High binding affinity between JA and KRAS G12D
In silico molecular docking analysis was conducted to predict the interactions between JA and wild-type (WT) KRAS, as well as its mutant variants (G12D, G12V, and G12C) (Fig. 2). The docking…
Category: 5. Biology
-
Fructooligosaccharides and Aspergillus enzymes increase brain GABA and homocarnosine by modulating microbiota in adolescent mice
Krnjevic, K. & Phillis, J. W. Iontophoretic studies of neurons in the mammalian cerebral cortex. J. Physiol. 165, 274–304 (1963).
Google Scholar
Barker-Haliski,…
Continue Reading
-
Correction: NF-κB-mediated EAAT3 upregulation in antioxidant defense and ferroptosis sensitivity in lung cancer
Correction: NF-κB-mediated EAAT3 upregulation in antioxidant defense and ferroptosis sensitivity in lung cancer
Continue Reading
-
Microglial TLR4-Lyn kinase is a critical regulator of neuroinflammation, Aβ phagocytosis, neuronal damage, and cell survival in Alzheimer’s disease
ARRIVE guidelines adherence
All experiments conformed to the ARRIVE guidelines for in vivo research50. These features ensure that our design is rigorous to deliver robust and unbiased results. Equal numbers of male and female mice were used, and…
Continue Reading
-
Comprehensive germline and somatic profiling of high-risk Thai breast cancer via next-generation sequencing
Spectrum of germline mutations in Thai patients with breast cancer and cross-ethnic comparisons
Blood samples from 1370 patients were subjected to germline mutation sequencing using a custom 36-core cancer panel (Supplementary Table 1). We found…
Continue Reading
-
How this tiny snake could change our view of genetics
The flowerpot snake, one of the world’s smallest snakes, has some unusual distinctions. Also known as the Brahminy blind snake, it’s the only known snake species with three sets of chromosomes instead of two — and it can reproduce without a…
Continue Reading
-
Researchers Uncover 500 Million-Year-Old Origins of Human Appetite Hormone
A human appetite hormone, bombesin, also controls feeding in starfish, showing it evolved over 500 million years ago. A team of biologists at Queen Mary University of London has discovered that a neurohormone responsible for controlling appetite…
Continue Reading
-
Fat cells trigger liver stress through secreted lipids
The endoplasmic reticulum (ER) is the portion of the cell responsible for manufacturing and folding proteins. Proteins are essential for a wide range of cellular functions-as enzymes, transporters, hormones, antibodies, receptors,…
Continue Reading
-
Sensing sickness: New method for boosting bee health
Beekeepers in the United States lost more than 55 percent of managed colonies last year — the highest loss rate since the Apiary Inspectors of America began determining them in 2011. A new study from University of Vermont scientists and…
Continue Reading
-
Plant doctor: An AI system that watches over urban trees without touching a leaf
Urban trees and plants do more than just beautify city landscapes. They purify the air, reduce urban heat islands, provide recreational spaces, and even boost property values. As essential components of sustainable urban ecosystems, plants…
Continue Reading