Correction: NF-κB-mediated EAAT3 upregulation in antioxidant defense and ferroptosis sensitivity in lung cancer
Category: 5. Biology
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Correction: NF-κB-mediated EAAT3 upregulation in antioxidant defense and ferroptosis sensitivity in lung cancer
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Microglial TLR4-Lyn kinase is a critical regulator of neuroinflammation, Aβ phagocytosis, neuronal damage, and cell survival in Alzheimer’s disease
ARRIVE guidelines adherence
All experiments conformed to the ARRIVE guidelines for in vivo research50. These features ensure that our design is rigorous to deliver robust and unbiased results. Equal numbers of male and female mice were used, and…
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Comprehensive germline and somatic profiling of high-risk Thai breast cancer via next-generation sequencing
Spectrum of germline mutations in Thai patients with breast cancer and cross-ethnic comparisons
Blood samples from 1370 patients were subjected to germline mutation sequencing using a custom 36-core cancer panel (Supplementary Table 1). We found…
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Syntaxin-6 mediated autophagy confers lenvatinib resistance in hepatocellular carcinoma
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71:209–49.
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Genetic and neural mechanisms shared by schizophrenia and depression
Fava M, Kendler KS. Major depressive disorder. Neuron. 2000;28:335–41.
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Owen MJ, Sawa A, Mortensen PB. Schizophrenia. Lancet. 2016;388:86–97.
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TRIM21-mediated METTL3 degradation promotes PDAC ferroptosis and enhances the efficacy of Anti-PD-1 immunotherapy
Cell culture and reagents
The cells utilized in this study were obtained from the American Type Culture Collection (ATCC, Manassas, VA), unless otherwise indicated. HPDE6C7 and AsPC-1 cells were cultured in RPMI-1640 medium (Gibco, NY, USA), while…
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Impact of a Terahertz electromagnetic field on the ion permeation of potassium and sodium channels
Structural analysis
We first computed the pore radius of each ion channel using HOLE46 after equilibration to confirm that they adopt a stably open state (Fig. 1 right panels). The pore radius of Kv1.2 was 0.60 Å at SF and 2.90 Å at the…
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Comparative single-nucleus RNA-seq analysis revealed localized and cell type-specific pathways governing root-microbiome interactions
Establishing a single-cell atlas of root responses to rhizosphere microbes with different lifestyles
Here, we employed a 48-well plate-based hydroponic root-microbe interaction system4,21 to segregate roots and leaves using a mesh and maintain…
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A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID
Protein biochemistry and structural biology
Reagents
Ubiquitin Rhodamine110 (UbRh, UbiQ Bio, UbiQ-002), isopropyl ß-D-1-thiogalactopyranoside (IPTG, Gold-Bio #I2481C100), β-mercaptoethanol (Sigma M3148), imidazole (Sigma 56749), lysozyme…
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Ursodeoxycholic acid prompts glycolytic dominance, reductive stress and epithelial-to-mesenchymal transition in ovarian cancer cells through NRF2 activation
Torre LA, Trabert B, DeSantis CE, Miller KD, Samimi G, Runowicz CD, et al. Ovarian cancer statistics, 2018. CA Cancer J Clin. 2018;68:284–96.
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Colombo N, Sessa C,…
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