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Category: 5. Biology
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TRIM21-mediated METTL3 degradation promotes PDAC ferroptosis and enhances the efficacy of Anti-PD-1 immunotherapy
Cell culture and reagents
The cells utilized in this study were obtained from the American Type Culture Collection (ATCC, Manassas, VA), unless otherwise indicated. HPDE6C7 and AsPC-1 cells were cultured in RPMI-1640 medium (Gibco, NY, USA), while…
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Impact of a Terahertz electromagnetic field on the ion permeation of potassium and sodium channels
Structural analysis
We first computed the pore radius of each ion channel using HOLE46 after equilibration to confirm that they adopt a stably open state (Fig. 1 right panels). The pore radius of Kv1.2 was 0.60 Å at SF and 2.90 Å at the…
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Comparative single-nucleus RNA-seq analysis revealed localized and cell type-specific pathways governing root-microbiome interactions
Establishing a single-cell atlas of root responses to rhizosphere microbes with different lifestyles
Here, we employed a 48-well plate-based hydroponic root-microbe interaction system4,21 to segregate roots and leaves using a mesh and maintain…
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A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID
Protein biochemistry and structural biology
Reagents
Ubiquitin Rhodamine110 (UbRh, UbiQ Bio, UbiQ-002), isopropyl ß-D-1-thiogalactopyranoside (IPTG, Gold-Bio #I2481C100), β-mercaptoethanol (Sigma M3148), imidazole (Sigma 56749), lysozyme…
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Ursodeoxycholic acid prompts glycolytic dominance, reductive stress and epithelial-to-mesenchymal transition in ovarian cancer cells through NRF2 activation
Torre LA, Trabert B, DeSantis CE, Miller KD, Samimi G, Runowicz CD, et al. Ovarian cancer statistics, 2018. CA Cancer J Clin. 2018;68:284–96.
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Colombo N, Sessa C,…
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Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank
Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank
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Plasmid-driven strategies for clone success in Escherichia coli
Donnenberg, M. Escherichia Coli: Pathotypes and Principles of Pathogenesis (Academic Press, 2013).
Massot, M. et al. Phylogenetic, virulence and antibiotic resistance characteristics of commensal strain populations of Escherichia coli from…
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Mechanisms of chromatin remodeling by the human Snf2-type ATPase SNF2H
Chromatin remodelers play a crucial role in the organization of chromatin. All known remodeler enzymes use an Snf2-type ATPase motor to slide nucleosomal DNA around the histone octamer,1,2 but the…
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