Category: 5. Biology

All procedures have been approved by the Biomedical Research Ethics Committee of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, under permit number ER-SIBS-221603P (version 20160310). They comply with national and local…

IgE specific for inhaled allergens mediates airway hypersensitivity in asthma, a chronic condition with intermittent symptoms driven by allergen re-exposure. However, IgE-expressing B cells fail to form memory B cells (MBCs) and long-lived IgE⁺…

The term Ductular reaction (DR) was coined by Hans Popper in 1957 and refers to a complex cellular response characterized by bile duct hyperplasia observed in the liver during various hepatic insults and pathological conditions [1]. The DR is a…

Generation Scotland

Volunteer recruitment to GS has been detailed in a previous publication⁴¹. Between 2006 and 2011, patients of collaborating general medical practices in Scotland between 35 and 65 years of age were selected at random and…

The opioid analgesic JTC801 can induce pH-dependent cell death, referred to as alkaliptosis, in pancreatic ductal adenocarcinoma (PDAC) cells independent of opioid receptors. This mode of death relies on intracellular alkalinization, with…

This study reveals strong correlations between chloroplast cluster features, spatial patterns, stomatal morphology parameters, and leaf greenness, particularly within Stage C cacao leaves. These findings highlight the dynamic developmental…

We developed a fully automated HISCL system for high-throughput detection of binding site–specific antibodies in patient specimens. By measuring region-specific antibody titers, this system enables detailed analysis of how individual epitopes…

Supplementary Fig. 1 presents the detailed process of this study.

Data collection and preprocessing

RNA-sequencing data consisting of 178 tumor samples and four normal samples with clinical information, including survival duration and pathological…