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Category: 5. Biology
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Targeting SCD triggers lipotoxicity of cancer cells and enhances anti-tumor immunity in breast cancer brain metastasis mouse models
SCD inhibition reshapes the lipid composition of breast cancer cells
To confirm the on-target effect and evaluate the influence of YTX-7739 (hereafter referred to as SCDi) on fatty acid synthesis flux in our model, triple-negative breast cancer…
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Causes and consequences of insect decline in tropical forests
Van Klink, R. et al. Meta-analysis reveals declines in terrestrial but increases in freshwater insect abundances. Science 368, 417–420 (2020).
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Lister, B. C. & Garcia, A….
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Lentogenic avian paramyxovirus 1 of both class I and class II are circulating in danish wild and commercial waterfowl
In this study, we characterised APMV-1 viruses isolated from wild and commercial birds in Denmark. In total, 32 APMV-1 viruses were isolated in Denmark during 2014-2022. The majority of the viruses (29/32) were found in apparently healthy birds….
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Nanopore sensing of protein and peptide conformation for point-of-care applications
Bellantuono, I. Find drugs that delay many diseases of old age. Nature 554, 293–295 (2018).
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Califf, R. M. Biomarker definitions and their applications. Exp….
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Correction: Small molecule induces mitochondrial fusion for neuroprotection via targeting CK2 without affecting its conventional kinase activity
Correction: Small molecule induces mitochondrial fusion for neuroprotection via targeting CK2 without affecting its conventional kinase activity
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Long-read genome and RNA sequencing resolve a pathogenic intronic germline LINE-1 insertion in APC
Rahman, N. Realising the promise of cancer predisposition genes. Nature 505, 302–308 (2014).
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Groden, J. et al. Identification and characterization…
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How mood-related physiological states bias economic decisions
Separate exploratory and confirmatory samples (total N = 94; see Supplementary Table 1 for a demographic overview) were recruited to assess the effects of happiness and sadness inductions on economic choices. For all behavioural data (ratings…
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Author Correction: A fast approach for structural and evolutionary analysis based on energetic profile protein comparison
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate…
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A comprehensive genetic landscape of inherited retinal diseases in a large Pakistani cohort
Clinical and demographic data
Our cohort comprised a total of 722 IRD patients, belonging to 213 different and unrelated families. Of the index patients, 115 (54%) were female and 98 (46%) were male. Most of the patients (156, 73.3%) were from the…
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