Participants
Data were collected as part of a larger, multi-visit study to investigate the cognitive and neural correlates of psychiatric disorders at the Laureate Institute for Brain Research (LIBR), with participants recruited from the community…
Category: 5. Biology
-
A bifunctional snoRNA with separable activities in guiding rRNA 2’-O-methylation and scaffolding gametogenesis effectors
Strains and plasmids
The Schizosaccharomyces pombe strains used in this study are listed in Supplementary Table 1 and were generated by lithium acetate-based transformation using complete medium (YE Broth, Formedium, #PMC0105) supplemented with…
Continue Reading
-
Inhibition of mitochondrial complex I induces mitochondrial ferroptosis by regulating CoQH2 levels in cancer
Cell lines and reagents
The SKOV3, PLC/PRF/5, ES-2, HT-1080, HCT-116, NCI-H23, and NCI-H1650 cell lines were obtained from the American Type Culture Collection (ATCC). Huh7 cells were obtained from the Cell Bank of the Chinese Academy of Sciences…
Continue Reading
-
Global structural survey of the flagellotropic myophage φTE infecting agricultural pathogen Pectobacterium atrosepticum
We used cryo-EM to reconstruct the complete φTE particle. In its native state, the particle is composed of a large T = 13 d icosahedral capsid adjoined to a narrow connector region, a helical rigid sheathed tail ~1020 Å in length, and a…
Continue Reading
-
Behavioral and neurofunctional profiles of delay aversion in children with attention-deficit hyperactivity disorder
Sonuga-Barke EJS. Causal models of attention-deficit/hyperactivity disorder: from common simple deficits to multiple developmental pathways. Biol Psychiatry. 2005;57:1231–8.
Google Scholar
Nigg JT,…
Continue Reading
-
Prognostic significance of clinicopathological and ultrasonographic features in anaplastic thyroid carcinoma beyond TERT promoter mutation
In this study, the TERT promoter mutation in ATC was associated with a larger tumor size but did not exhibit significant differences in other clinicopathological characteristics or US features compared to ATC without the mutation. Notably, ATC…
Continue Reading
-
Molecular basis for the interaction between Saccharomyces cerevisiae Rtt103 and the Rat1-Rai1 complex
Overall structure of Rat1-Rai1-Rtt103 ternary complex
To produce the Rat1-Rai1-Rtt103 complex, we first tried to express the three proteins separately in E. coli and assemble them in vitro. Although Rat1 and Rtt103 could be expressed and purified,…
Continue Reading
-
Mitochondrial, metabolic and bioenergetic adaptations drive plasticity of colorectal cancer cells and shape their chemosensitivity
A subgroup of CRC cells displays drastically reduced mitochondrial biomass
CRC exhibit remarkable heterogeneity dividing them into four molecular subtypes (CMS1-4), which are additionally characterized by features such as microsatellite…
Continue Reading
-
Cytogenetic signatures favoring metastatic organotropism in colorectal cancer
Characterization of the CRCTropism cohort
The CRCTropism cohort comprised a total of 314 tumors derived from 191 patients diagnosed with metastatic CRC. Demographic and clinic-pathological data of this cohort are summarized in Supplementary…
Continue Reading
-
Improved post-transplant outcomes for elderly acute myeloid leukemia patients conditioned with FLU/BU4 rather than conventional MAC regimens
Characteristics of patients and transplants
A total of 6551 AML patients who underwent allogenic HSCT with MAC regimens were extracted from the Japanese nationwide registry. Among them, 905 patients received FLU/BU4, while 5646 patients received…
Continue Reading