From toddlers in daycare to seedlings in forests, young organisms tend to get sick more easily than adults — a phenomenon that has long puzzled parents and scientists alike.
University of Maryland biologists offer new insights into this…
Category: 5. Biology
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Best methods for growing Atlantic sea scallops
A new study from the University of Maine’s Aquaculture Research Institute (ARI) and Darling Marine Center is helping to refine best practices for growing Atlantic sea scallops (Placopecten magellanicus), a species of increasing interest to…
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TransBind allows precise detection of DNA-binding proteins and residues using language models and deep learning
We first briefly present our proposed method TransBind. Next, we report, on an extensive evaluation study, the performance of TransBind compared to the state-of-the-art DNA protein binding prediction methods on a collection of widely used…
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Exome sequencing reveals low-frequency and rare variant contributions to multiple sclerosis susceptibility in Turkish families
I. M. S. G. Consortium*\(\dagger\) et al. Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility. Science 365, eaav7188. https://doi.org/10.1126/science.aav7188 (2019).
Breedon, J. R. et al. Polygenic…
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Preclinical concept studies showing advantage of an inhaled anti-CTGF/CCN2 protein for pulmonary fibrosis treatment
Ethics statement
All experiments involving human lung tissues were performed in accordance with the Declaration ofHelsinki and written informed consent was obtained from all participants. Ethical approval of the studies is highlighted in the…
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Nanoparticles of banana peels as a potential source of bioactive compounds and their activities on HepG2
Bezerra, C. V., Rodrigues, A. M. D. C., Amante, E. R. & Silva, L. H. M. D. Nutritional potential of green banana flour obtained by drying in spouted bed. Rev. Bras. Frutic. 35, 1140–1146 (2013).
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Cooperative role of PACT and ADAR1 in preventing aberrant PKR activation by self-derived double-stranded RNA
CRISPR-Translate: A CRISPR-Cas9 screening method to identify factors regulating translation during viral infection
To reveal key factors that regulate PKR in response to viral infections, we applied the CRISPR Translate method, a FACS-based…
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Time-warping analysis for biological signals: methodology and application
Sakoe, H. & Chiba, S. Dynamic programming algorithm optimization for spoken word recognition. IEEE Trans. Acoust. 26, 43–49 (1978).
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Bruderlin, A. & Williams, L. Motion signal…
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Single-cell transcriptional responses of T cells during microsporidia infection
Han, B. & Weiss, L. M. Microsporidia: obligate intracellular pathogens within the fungal kingdom. Microbiol. Spectr. 5, https://doi.org/10.1128/microbiolspec.funk-0018-2016 (2017).
Han, B. et al. The role of microsporidian polar tube protein 4…
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Pitolisant alleviates brain network dysfunction and cognitive deficits in a mouse model of Alzheimer’s disease
Subject
This study followed the guidelines approved by the Animal Ethics Committee of Guangxi University. We used heterozygous 5xFAD mice (Tg6799, C57BL6), which express mutant human APP and PSEN1 (APP KM670/671NL: Swedish, I716V: Florida, V717I:…
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