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Li, X., Alvarez, B., Casey, J….
Category: 5. Biology
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Spatially informed graph transformers for spatially resolved transcriptomics
Overview of SpaGT
We developed SpaGT, a spatially informed graph transformer framework designed specifically for spatially resolved transcriptomics (SRT) analysis. SpaGT enables the learning of spatially aware graph representation for denoising…
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Aneuploidy confers a unique transcriptional and phenotypic profile to Candida albicans
C. albicans gene expression correlates with relative copy number
Diploid C. albicans SC5314 strains were mated to generate tetraploid products that were then induced to undergo CCL by incubation on pre-sporulation…
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Targeting alveolar epithelial cells with lipid micelle-encapsulated necroptosis inhibitors to alleviate acute lung injury
Mice
Male C57BL/6 mice, aged 6-8 weeks, weighing between 16-24 grams, were purchased from SHANGHAI SLAC LABORATORY ANIMAL CO.LTD., and were acclimated for one week in the animal laboratory of the Clinical Research Center of the Second Affiliated…
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Selenomethionine inhibits the proliferation of hypoxia-induced pulmonary artery smooth muscle cells by inhibiting ROS and HIF-1α-ACE-AngII axis
Isolation and cell culture of PASMCs
The experimental animals used in the study were male Sprague-Dawley (SD) rats, specific pathogen free (SPF) grade, 5 weeks of age. The weight was (130 ± 10) g, which was purchased from Beijing Huafu…
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ESM-Ezy: a deep learning strategy for the mining of novel multicopper oxidases with superior properties
Materials
All chemicals used in this study were of analytical grade or higher. Plasmids for the expression of various multicopper oxidases (MCOs) were synthesized by SynbioB (Tianjin, China). LB broth powder, Isopropyl β-d-1-thiogalactopyranoside…
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Suboptimal pre-anthesis water status mitigates wheat susceptibility to fusarium head blight and triggers specific metabolic responses
Stevens, R. B. Cultural practices in disease control. in Plant Pathology: An Advanced Treatise (eds Horsfall, J. G. & Dimond, A. E.) 3, 357–429 (Academic, 1960). https://doi.org/10.1016/B978-0-12-395678-1.50016-3.
Francisco, C. S., Ma, X.,…
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Enhancing venetoclax efficacy in leukemia through association with HDAC inhibitors
Portela A, Esteller M. Epigenetic modifications and human disease. Nat Biotechnol. 2010;28:1057–68.
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Dai Z, Ramesh V, Locasale JW. The evolving metabolic landscape of…
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Letter to the editor: Comments on ‘Striking long-term beneficial effects of single-dose psilocybin and psychedelic mushroom extract in the SAPAP3 rodent model of OCD-like excessive self-grooming’ by Brownstien et al. (2024)
Pedicini M, Cordner ZA. Utility of preclinical models in the study of psilocybin–a comprehensive review. Neurosci Biobehav Rev. 2023;146:105046.
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Gattuso JJ,…
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Testosterone dynamics of migratory birds during stopover
Ramenofsky, M. & Wingfield, J. C. Behavioral and physiological conflicts in migrants: the transition between migration and breeding. J. Ornithol. 147(2), 135–145 (2006).
Aispuro, A. A.,…
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