The complete article selection process is shown in Fig. 1. After identifying the included articles, the study team performed a comprehensive full-text review of the resulting 49 studies. There were 30 studies on data analysis and 20 studies on…
Category: 5. Biology
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The MacqD deep-learning-based model for automatic detection of socially housed laboratory macaques
Data collection
A collection of video recordings, subsequently referred as Macaque data, was acquired at the macaque research facility of Newcastle University, UK, between 2014 and 2020. The facility complies with the NC3Rs Guidelines for…
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Mechanistic insights into the structure-based design of a CspZ-targeting Lyme disease vaccine
Ethics statement
All mouse experiments were performed in strict accordance with the provisions of the Animal Welfare Act, the Guide for the Care and Use of Laboratory Animals, and the PHS Policy on Humane Care and Use of Laboratory Animals. The…
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Author Correction: Brain milieu induces early microglial maturation through the BAX-Notch axis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate…
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Human induced pluripotent stem cell-derived cardiomyocytes and their use in a cardiac organ-on-a-chip to assay electrophysiology, calcium and contractility
Tsao, C. W. et al. Heart disease and stroke statistics—2023 update: a report from the American Heart Association. Circulation 147, e93–e621 (2023).
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Gwathmey, J….
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Far-red fluorescent genetically encoded calcium ion indicators
Ethics statement
This research complies with all relevant ethical regulations. Procedures for preparation of primary neurons at Université Laval were approved by the Animal Ethics Committee and were performed according to Canadian Biosafety…
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Brain Channels “Stopped in Time” Reveal How We Think and Learn
Scientists used advanced cryo-EM imaging to reveal how glutamate activates brain receptors, paving the way for new neurological treatments. To better understand how brain cells communicate using chemical signals, scientists have used a highly…
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Study uses body’s clock to deliver medication precisely when needed
In vivo characterization of Per2-IL1Ra-t2a-Luc chronotherapy circuit. Credit: Nature Communications (2025). DOI: 10.1038/s41467-025-56584-5
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CRISPRi-based screen of autism spectrum disorder risk genes in microglia uncovers roles of ADNP in microglia endocytosis and synaptic pruning
Human iPSC culture
iPSCs were cultured on Matrigel (Corning; Cat. No. 356231) coated vessels in StemFlex Media (Gibco; Cat. No. A3349401) until 80% confluent. Upon confluency, cells were washed with DPBS (Gibco; Cat. No. 14190-144), lifted using…
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Computational insights into exploring the potential effects of environmental contaminants on human health
Analysis of carcinogenic molecule clustering
Carcinogenic molecules were first collected from public databases and subjected to preprocessing, including de-duplication and SMILES standardization, yielding 5,041 unique compounds. To refine the…
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