By calibrating global change models with recent 1.5-°C country-specific climate pledges, Gao et al. generated maps that quantify land-system type transformations over the next 75 years. Whereas previous research (P. Potapov et al. Nat. Food 3,…
Category: 5. Biology
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Variation in defensive and exploratory behaviors across a rattlesnake (Crotalus scutulatus × viridis) hybrid zone in Southwestern new Mexico
MacKinlay, R. D. & Shaw, R. C. A systematic review of animal personality in conservation science. Conserv. Biol. e13935 https://doi.org/10.1111/cobi.13935 (2022).
Bell, A. M., Hankison, S. J. & Laskowski, K. L. The repeatability of behaviour: a…
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Brief blockade of type I IFN increases CD8+ T cell memory
Stem cell-like memory CD8+ T (TSCM) cells are crucial for long-lived immune memory. But it is not clear how best to induce this population with vaccines or immunotherapy. A study now shows that transient blockade of type I interferon receptor…
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Transcriptomic and morphologic vascular aberrations underlying FCDIIb etiology
Transcriptomic and cellular alternations in FCDIIb
To systematically investigate the cellular and molecular pathways underlying the etiology of FCDIIb, we performed unbiased snRNA-seq on 15 pairs of lesions and adjacent neocortical brain tissues…
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An Oryza-specific histone H4 variant predisposes H4 lysine 5 acetylation to modulate salt stress responses
Kornberg, R. D. Chromatin structure: a repeating unit of histones and DNA. Science 184, 868–871 (1974).
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Hocher, A. et al. Histones with an unconventional…
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A naturally selected αβ T cell receptor binds HLA-DQ2 molecules without co-contacting the presented peptide
Discovery of a peptide independent CD4+ T cell restricted to HLA-DQ2.5
Using tetramer based magnetic enrichment10,11 and single cell index sorting approaches, we isolated CD4+ T cells binding to HLA-DQ2.5 (DQA1*05:01/DQB1*02:01) tetramers…
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Structural basis for allosteric agonism of human α7 nicotinic acetylcholine receptors
Nemecz, A., Prevost, M. S., Menny, A. & Corringer, P. J. Emerging molecular mechanisms of signal transduction in pentameric ligand-gated ion channels. Neuron 90, 452–470 (2016).
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Evaluation of novel and traditional anthropometric indices for predicting metabolic syndrome and its components: a cross-sectional study of the Nepali adult population
Our study revealed a high prevalence of MetS in the Nepali cohort. There was a significant sex disparity, with females showing higher rates than males. This aligns with recent studies in South Asian populations reporting a higher MetS incidence…
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L-asparaginase is a PAR2 N-terminal protease that unmasks the PAR2 tethered ligand
Materials
Dulbecco’s modified Eagle medium (DMEM)/F12, DMEM and RPMI1640 were from Thermo Fischer (ON, Canda). JetPRIME transfection reagent was from Polyplus transfection (NY, USA). L-asparaginase (ab277068) was from Abcam (ON, Canada)….
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