Sphere Bio, a leading provider of picodroplet-based microfluidics for functional single-cell analysis and isolation, today announced a significant expansion of its APAC distributor network. This development marks a key milestone in…
Category: 5. Biology
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Scientists Discover Hidden Hormone That Triggers Ovulation
Could this be nature’s secret fertility potion? An international team of researchers has discovered a new sex hormone that plays a key role in triggering ovulation. The hormone, secretoneurin, a neuropeptide derived from the protein…
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Study uncovers conserved development and evolutionary innovations in the human hypothalamus
The hypothalamus is a small but critical region at the base of the brain that controls the autonomic nervous system, regulates body temperature, signals hunger and thirst, exerts hormonal control over the pituitary…
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New discovery promises to revolutionize liver organoid development
Organoids are small-scale models that mimic human organs. These models could help scientists understand diseases and test treatments, and potentially aid in regenerative therapeutic methods. Organoids derived from human induced…
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Differential response of tissue engineered skeletal muscle from rheumatoid arthritis patients and healthy controls
Donor characteristics
Skeletal muscle biopsies of the vastus lateralis were obtained from 6 RA patients, aged 61–79 (BMI 21.2–31.9) and 5 age-matched healthy controls, aged 62–76 (BMI 20.6–32.9). All 6 RA patients were female…
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Development of a breast cancer invasion score to predict tumor aggressiveness and prognosis via PI3K/AKT/mTOR pathway analysis
Cellular Atlas of Ductal Carcinoma
This study performed a comprehensive analysis of the scRNA-seq dataset GSE195861 and constructed a cellular atlas based on it. The dataset contains 20 tissue samples, including 1 from Normal sample, 7 from…
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Application and exploration of garbage enzymes in soil remediation of multiple heavy metal pollution
Liu, H. et al. Heavy metal ATPase 3 (HMA3) confers cadmium hypertolerance on the cadmium/zinc hyperaccumulator Sedum Plumbizincicola. New. Phytol. 215 (2), 687–698 (2017).
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A copy number variant overlapping the 3ʹUTR of PLP1 causes spastic paraplegia
Bonkowsky JL, Nelson C, Kingston JL, Filloux FM, Mundorff MB, Srivastava R. The burden of inherited leukodystrophies in children. Neurology. 2010;75:718–25.
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Mosaic deletions detected by genome sequencing in two families
Wojcik MH, Lemire G, Berger E, Zaki MS, Wissmann M, Win W, et al. Genome Sequencing for Diagnosing Rare Diseases. N Engl J Med. 2024;390:1985–97.
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The AKAP12-PKA axis regulates lipid homeostasis during alcohol-associated liver disease
Cell culture and treatments
Cryopreserved, plateable, primary human hepatocytes were purchased from ThermoScientific (Rockford, IL). Cells were passed through percoll-containing density gradient medium (Cytiva, Marlborough) and further washed and…
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