PTB is a significant infectious disease that poses a severe threat to the health of people globally. The heterogeneity of PTB infection, onset, and treatment, aside from differences in individual genetic background, the resident microbial flora…
Category: 5. Biology
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Effect of neurohormonal therapeutic in left ventricle global and regional function in Chagas cardiomyopathy in a translational animal experimental model
The experimental animal model of CD in Syrian hamsters simulates CCC with the same characteristics as human disease. Left ventricle remodeling and myocardial dysfunction can be assessed by echocardiography dedicated to small animal models,…
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Design, synthesis and optimization of TarO inhibitors as multifunctional antibiotics against Methicillin-resistant Staphylococcus aureus
General procedure for synthesis of compounds 1–7
To a 25 mL two-necked flask equipped with a magnetic stirrer was added 31a (0.5 mmol, l.0 equiv). The flask was then placed at -78 °C and 5 mL anhydrous THF was added under nitrogen….
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MGP regulates the adipogenic differentiation of mesenchymal stem cells in osteoporosis via the Ca2+/CaMKII/RIP140/FABP3 axis
Isolation and culture of MSCs
The study received approval from The Ethics Committee of The Eighth Affiliated Hospital, Sun Yat-sen University. Subsequently, ten patients diagnosed with osteoporosis (OP) and ten non-osteoporotic control subjects…
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Population genetic structure and demographic history of Dermacentor marginatus Sulzer, 1776 in Anatolia
A total of 938 (360♂♂, 578♀♀) host-seeking adult D. marginatus individuals were collected from 151 pinpoint locations across 31 sampling sites. This included 553 individuals from 102 locations within 19 sampling sites in CN and 256…
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Single-cell RNA sequencing characterization of Holstein cattle blood and milk immune cells during a chronic Staphylococcus aureus mastitis infection
All cows developed chronic mastitis infections, confirmed by bacterial plating and somatic cell counts (SCC), following S. aureus challenge with strain Newbould 305. Post-infection, animals averaged 2.82 × 106 ± 1.08 × 106 somatic…
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KPNA2 promotes osteosarcoma progression by regulating the alternative splicing of DDX3X mediated by YBX1
Differentially expressed gene (DEG) and alternative splicing analysis
The RNA sequencing data of 23 primary osteosarcomas, 8 metastatic osteosarcomas, and 3 normal tissues were derived from the NCBI Gene Expression Omnibus database coded as…
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Evaluation on the clinical findings and allergological factors of local allergic conjunctivitis and non-local allergic conjunctivitis
In 2019, we reported the existence of LAC in ACD2, which is characterized by the presence of sensitizing IgE in the conjunctiva and tears, but has no abnormalities in systemic s-IgE or s-sIgE. In this study, we investigated the characteristics of…
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Clinical and molecular description of natural infections with an Asian strain of lumpy skin disease virus in Bos indicus
This study described the clinical outcomes of natural infections with an isolate of LSDV in Bos indicus in the tropical region of Indonesia, as well as seroconversion and the viral DNA load in circulating blood. Bos indicus has been known to be…
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Targeting fungal lipid synthesis for antifungal drug development and potentiation of contemporary antifungals
Denning, D. W. Global incidence and mortality of severe fungal disease. Lancet Infect Dis. 24, e428–e438 (2024).
Kainz, K. et al. Fungal infections in humans: the silent crisis. Micro. Cell 7, 143–145 (2020).
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