Nakamura K, Kodera H, Akita T, Shiina M, Kato M, Hoshino H, et al. De Novo mutations in GNAO1, encoding a Gαo subunit of heterotrimeric G proteins, cause epileptic encephalopathy. Am J Hum Genet. 2013;93:496–505.
Category: 5. Biology
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The study of outdoor thermal comfort in open spaces of cold climate campus
Descriptive analysis
Basic information of respondents
In this study, we conducted field research with 901 volunteers and obtained 820 valid responses. The majority of the volunteers were students, accounting for 87.8% of the valid data. The…
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Transformer-based deep learning for accurate detection of multiple base modifications using single molecule real-time sequencing
Structure of HK model 2
Figure 1 shows a schematic of the design of HK model 2. Kinetic signals of SMRT-seq including IPDs and PWs, the corresponding base identity, and base positions within a 21-nucleotide (nt) measurement window were organized…
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Engineering biology applications for environmental solutions: potential and challenges
Hassard, F. et al. Scaling-up engineering biology for enhanced environmental solutions. ACS Synth. Biol. 13, 1586–1588 (2024).
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Leukoreduction filter derived NK cells offer a promising source for off the shelf CAR NK cell immunotherapy
Cell culture
The human BCMA+ multiple myeloma cell line (U266-B1), BCMA- acute lymphoblastic leukemia cell line (CCRF-CEM), human erythroleukemic cell line (K562), and human embryonic kidney cell line (HEK293T) were procured from the Pasteur…
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Integrated renin angiotensin system dysregulation and immune profiles predict COVID-19 disease severity in a South African cohort
Viruses cause pathology via direct cytopathy with associated tissue damage, via secondary immune damage and perturbations of normal host physiology. The SARS-CoV-2 pandemic highlighted the importance of immune-driven tissue injury, as well as the…
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Identification of serum metabolite biomarkers and metabolic reprogramming mechanisms to predict recurrence in cholangiocarcinoma
Cholangiocarcinoma (CCA) has a high recurrence rate after surgical resection, with the recurrence-free interval being a key factor in disease severity and survival. Early recurrence, occurring within 6 months to 1 year, is associated with…
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Identification of novel inhibitors targeting Mycobacterium abscessus InhA through virtual screening, docking, and molecular dynamic simulations
Data retrieval
In this study, the pharmacophore hypothesis was developed based on previously documented inhibitor IC25 of MAB16. An overview of reported inhibitors, including their MIC values and structures, is presented in (Table 1).
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Biodiversity change is more than the sum of its parts
Addressing biodiversity loss requires reliable summaries and predictions of biodiversity change to support decisions, actions and policies. In theory, biodiversity change is understood to be the combined response of intertwined species to global…
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