mPFC-NAc and vHip-NAc similarly encode outcomes in a probabilistically rewarded environment
To assess redundancy versus specificity in outcome encoding in two distinct circuits under matched conditions and trial histories, we injected retrograding…
Category: 5. Biology
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Programmable protein stabilization with language model-derived peptide guides
Binder design
The β-cat_SnP_7 peptide10, β-cat_SnP_8 peptide10, P60D2A peptide27, and YFP nanobodies13 were described in previous works and obtained from respective manuscript metadata. Binding peptides designed in this study were either…
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Blood proteome profiling for biomarker discovery in broilers with necrotic enteritis
Biomarkers and surrogate endpoints. Preferred definitions and conceptual framework. Clin. Pharmacol. Ther. 69, 89–95 (2001).
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Lee, J. W. et al. Fit-for-Purpose method development…
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Author Correction: Combinatorial selective ER-phagy remodels the ER during neurogenesis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate…
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The effect of H2O2 on elongation growth and oxidative stress in maize coleoptile cells treated with auxin and fusicoccin
Khalid, M. F. et al. Impacts of abiotic stresses on growth and development of plants. In Plant Tolerance to Environmental Stress (eds Hasanuzzaman, M. et al.) 1–8 (CRC Press, 2019). https://doi.org/10.1201/9780203705315-1.
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Reposition of lenalidomide as a radiation protector based on LINCS gene expression signatures and its preclinical validation
Library of integrated network‑based cellular signatures (LINCS)
The cellular expression signatures of all compounds used in this study were collected and extracted from LINCS of National Institutes of Health (https://commonfund.nih.gov/LINCS)….
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The inhibitory effect of Osthole on A549 lung adenocarcinoma cells and its biomarker
Cytopathic effect
MTT assay was used to investigate the cytopathic rate (CR) of 8 selected compounds and Cisplatin (positive control drug) to find out its MNTC and CC50 values. The chemical structures of selected compounds were shown in Fig. 1A….
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MGAT1-Guided complex N-Glycans on CD73 regulate immune evasion in triple-negative breast cancer
Accumulation of MGAT1, a glycosyltransferase, is associated with an unfavorable tumor immune response and prognosis in immune-cold breast cancers
To search for potential therapeutic targets for immune-cold breast cancer, we performed a…
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Engineering intercellular communication using M13 phagemid and CRISPR-based gene regulation for multicellular computing in Escherichia coli
Establishing a M13 phagemid system for intercellular communication
For gene regulation in our engineered microbial consortium of E. coli strains we employ CRISPRi21,34. To establish communication between consortium members, we combined CRISPRi…
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Pneumocystis jirovecii is a potential pivotal ecological driver contributing to shifts in microbial equilibrium during the early-life lower airway microbiome assembly
Lungs contain a distinct microbiome from microbial contaminant controls
Studies suggested that the presence of microorganisms in the lower respiratory tract might contribute to the course of airway diseases. However, one challenge in working with…
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