Alzheimer’s Association. Alzheimer’s disease facts and figures. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring. 2022;18:700–89.
Hardy J, Duff K, Hardy KG, Perez-Tur J,…
Category: 5. Biology
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C12ORF49 inhibits ferroptosis in hepatocellular carcinoma cells via reprogramming SREBP1/SCD1-mediated lipid metabolism
Clinical specimens and reagents
HCC tumor and non-tumor tissues (n = 268) were acquired from patients diagnosed with hepatocellular carcinoma (HCC) at the Air Force Medical University in Xi’an, China. The tissue samples were obtained with…
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TRAPT: a multi-stage fused deep learning framework for predicting transcriptional regulators based on large-scale epigenomic data
Overview of TRAPT
TRAPT is a multi-omics framework of integration that is designed for inferring TR activity from a set of queried genes. In simple terms, the model takes interest genes as input and outputs the activity score for each TR (Fig. 1a…
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A stress-tolerant strain Rhodococcus sp. WH103 was isolated and co-immobilized to more efficiently degrade phenazine-1-carboxylic acid
Mavrodi, D. V., Blankenfeldt, W. & Thomashow, L. S. Phenazine compounds in fluorescent Pseudomonas spp. Biosynthesis and regulation. Annu. Rev. Phytopathol. 44, 417–445 (2006).
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The unusual genetic inheritance that could change Alzheimer’s treatment
Brain-tissue slides in Medellín, Colombia.Credit: Federico Rios Escobar/New York Times/Redux/eyevine
In 1982, neurologist Francisco Lopera and his colleagues at the University of Antioquia in…
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The phased pan-genome of tetraploid European potato
Spooner, D. M. et al. A single domestication for potato based on multilocus amplified fragment length polymorphism genotyping. Proc. Natl Acad. Sci. USA 102, 14694–14699 (2005).
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Dual modulation of cytotoxic and checkpoint receptors tunes the efficacy of adoptive Delta One T cell therapy against colorectal cancer
Ethical statement
This investigator-initiated study was conducted in accordance with the principles of the Declaration of Helsinki and the International Conference on Harmonization Good Clinical Practice guidelines and was approved by the ethics…
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MC4-R variant confirms its association with obesity during progression from childhood to adolescence
This small follow up study demonstrates that the rs12970134 variant near the melanocortin receptor 4 (MC4-R) not only explicates an obesogenic effect in the prepubertal age but remains a major risk factor also during post pubertal age. Pubertal…
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Algae octopus (Abdopus aculeatus) | Nature Ecology & Evolution
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Re-analysis of mobile mRNA datasets raises questions about the extent of long-distance mRNA communication
A key step in mobile mRNA studies is the assignment of RNA-seq reads to different genotypes. One way of identifying the genotype is based on single nucleotide polymorphisms (SNPs) (Fig. 1). Typically, a requirement is made for a defined number of…
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